Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation

Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation
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DOI:
10.1128/ec.00448-07
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发表时间:
2008-03-01
期刊:
影响因子:
--
通讯作者:
Kim, Kami
Kim, Kami
中科院分区:
其他
文献类型:
--
作者:
Gissot, Mathieu;Choi, Sang-Woon;Kim, Kami

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表观遗传因素在顶复门原虫毒力特性的表达中起作用。顶复门原虫的基因组编码假定的DNA胞嘧啶甲基化酶。为了评估刚地弓形虫和微小隐孢子虫DNA中胞嘧啶甲基化的情况,我们使用了质谱分析,并证实这些生物的DNA中缺乏可检测到的甲基胞嘧啶。
Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.