Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer
Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer
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DOI：
10.1111/j.1525-1438.2007.00932.x
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发表时间：
2007-11-01
影响因子：
4.8
通讯作者：
Araki, Y.
中科院分区：
文献类型：
--
作者：
Yoshitake, H.;Takahashi, M.;Araki, Y.
醛酮还原酶家族1，成员B10(AKR1B10)是一种将视网膜转化为视黄醇的酶，已知在非小细胞肺癌(鳞癌和腺癌)中检测到，但在正常组织中几乎不表达。由于这些类型的癌经常发生在子宫(如肺)，AKR1B10也可能在两种主要类型的子宫癌中过度表达，宫颈癌(CC)和子宫内膜癌(EMC)。本研究的目的是研究AKR1B10在子宫癌中的表达，并分析其临床意义。在子宫癌患者标本中，6例(20.0%)CC和6例(15.8%)EMC患者检测到AKR1B10。统计分析表明，AKR1B10的表达与鳞癌术后复发和角化有关。虽然在正常上皮中观察到视黄醇(AKR1B10的代谢产物)，但在AKR1B10阳性的CC标本的癌细胞中没有观察到该分子，这表明CC的复发可能不依赖于AKR1B10将视黄醇转化为视黄醇，AKR1B10是CC患者治疗的潜在指标。
Aldo-keto reductase family 1, member B10 (AKR1B10), an enzyme that converts retinals into retinols is known to detect in non-small cell lung carcinoma (squamous cell- and adeno-carcinomas), but is barely expressed in normal tissues. Since these types of carcinoma occur frequently in the uterus (like in the lung), AKR1B10 may also be overexpressed in two major types of uterine cancer, cervical cancer (CC), and endometrial cancer (EMC). The objective of this study is to investigate AKR1B10 expression in uterine cancer and to analyze its clinical significance. In samples from uterine cancer patients, AKR1B10 was detected in 6 out of 30 (20.0%) CC cases and 6 out of 38 (15.8%) EMC cases. Statistical analysis indicated that AKR1B10 expression was associated with tumor recurrence after surgery and keratinization of squamous cell carcinoma only in CC. Although retinol (a metabolic product by AKR1B10) was observed in the normal epithelium, the molecule was not observed in cancer cells of AKR1B10-positive CC samples suggesting that the recurrence in CC may not depend on the convert of retinals into retinols via AKR1B10, a potential indicator in the management of patients with CC.