Management of methamphetamine abuse and dependence.
Management of methamphetamine abuse and dependence.
复制标题
DOI：
10.1007/s11920-006-0035-x
复制
发表时间：
2006-10-01
影响因子：
6.7
通讯作者：
Ling, Walter
中科院分区：
文献类型：
--
作者：
Ling, Walter;Rawson, Richard;Ling, Walter
循证治疗和未来实践的初步影响可能来自新的研究结果，激发了对甲基苯丙胺依赖和相关医疗后果的新观点。目前的使用者群体包括受影响日益严重的亚群体（即青年、妇女、男男性行为者和农村居民）;在这些亚群体中滥用甲基苯丙胺的复杂后果需要作出更多的努力，涉及对特征的背景理解和开发有效治疗的需要。神经生物学数据的细胞活动的甲基苯丙胺采取的结果，从神经影像学研究表明潜在的目标，药理学干预。在早期的试验中，几种候选药物-安非他酮，莫达非尼，以及在较小程度上的巴氯芬-在治疗甲基苯丙胺依赖方面显示出希望，包括帮助记忆功能更有效地参与和受益于行为疗法。临床医生和研究人员必须相互作用，以有效地解决甲基苯丙胺依赖问题，这是美国和世界上的一个主要毒品问题。
Preliminary implications for evidence-based treatments and future practice may be drawn from new research findings that inspire a fresh view of methamphetamine dependence and associated medical consequences. Current user populations include increasingly impacted subgroups (ie, youths, women, men who have sex with men, and rural residents); complex consequences of methamphetamine abuse among these subgroups require additional efforts involving contextual understanding of characteristics and needs to develop effective treatments. The neurobiological data on cellular activity of methamphetamine taken with findings from neuroimaging studies indicate potential targets for pharmacologic interventions. In early trials, several candidate medications--bupropion, modafinil, and, to a lesser extent, baclofen--have shown promise in treating aspects of methamphetamine dependence, including aiding memory function necessary to more effectively participate in and benefit from behavioral therapies. Clinicians and researchers must interact to efficiently address the problems of methamphetamine dependence, a major drug problem in the United States and the world.