Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography
Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography
复制标题
三维光学相干断层扫描视网膜层光强度的定量分析。
DOI：
10.1167/iovs.13-12062
复制
发表时间：
2013-10-01
影响因子：
4.4
通讯作者：
Chen, Haoyu
中科院分区：
文献类型：
--
作者：
Chen, Xinjian;Hou, Ping;Chen, Haoyu
目的.采用自动化测量系统对正常人视网膜各层进行三维谱域光学相干断层扫描（SD-OCT）。40例正常受试者接受Topcon 3D OCT-1000黄斑中心扫描。使用3D图形搜索方法将原始数据自动分割成10层。然后计算各层强度的平均值和标准差。OCT软件给出图像质量指标。对各层光强与图像质量及受试者年龄进行相关性分析。视网膜神经纤维层（RNFL）、光感受器、视网膜色素上皮（RPE）和脉络膜之间光强相关性中等（0.410 < r < 0.800），玻璃体内光强相关性较低（0.251 < r < 0.541）。视网膜神经纤维层、感光层、视网膜色素上皮和脉络膜的光强与图像质量相关系数分别为0.748 < r < 0.802和0.869，玻璃体的光强与图像质量相关系数分别为0.528和0.528。RNFL的光强度与年龄呈负相关（r = -0.365）。实现了各层强度的自动评估。在正常人中，视网膜层的光学强度受图像质量的影响。建议使用ONL、所有区域或图像质量指数的光强度进行归一化。RNFL的光强度随年龄增长而降低。
PURPOSE. To investigate the optical intensities of all retinal layers on three-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) in normal subjects using an automatic measurement.METHODS. Forty normal subjects underwent Topcon 3D OCT-1000 macula-centered scan. The raw data were automatically segmented into 10 layers using the 3D graph search approach. Then the mean and standard deviation of intensities of each layer were calculated. The image quality index was given by the OCT software. Correlation analysis was performed between the optical intensities in each layer and image quality and subject's age.RESULTS. The correlation of optical intensities was strong from ganglion cell layer (GCL) to outer nuclear layer (ONL) with r > 0.934; moderate among retinal nerve fiber layer (RNFL), photoreceptor, retinal pigment epithelium (RPE), and choroid (0.410 < r < 0.800); and low in the vitreous (0.251 < r < 0.541). The optical intensities were also correlated with the image quality, r > 0.869 from GCL to ONL, 0.748 < r < 0.802 for RNFL, photoreceptor layer, RPE, and the choroid, r = 0.528 for the vitreous. The optical intensity in RNFL was negatively correlated with age (r = -0.365).CONCLUSIONS. Automatic assessment of the layers' intensities was achieved. In normal subjects, the retinal layers' optical intensities were affected by image quality. Normalization with optical intensity of ONL, all areas, or image quality index is recommended. The optical intensity of RNFL decreased with age.