Initial occupational exposure to lead: Chromosome and Biochemical findings.
Initial occupational exposure to lead: Chromosome and Biochemical findings.
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初次职业接触铅：染色体和生化结果。
DOI：
10.1080/00039896.1976.10667193
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
G. Secchi
中科院分区：
文献类型：
--
作者：
A. Forni;G. Cambiaghi;G. Secchi
对11名受试者在蓄电池厂职业暴露于中等剂量铅烟之前和期间进行了一系列的染色体和生化研究。异常中期率，主要是染色单体和一次断裂的染色体畸变率，在工作一个月后大约翻了一番；工作两个月后进一步增加；暴露七个月后保持在这个范围内；然后有下降的趋势。血铅水平在最初的几个月里逐渐上升，然后达到稳定状态。工作1个月后，尿铅和辅助性卟啉水平急剧上升，而尿β-氨基乙酰丙酸(ALA)水平中度上升。红细胞(RBC)的丙氨酸脱水酶(ALAD)活性在一个月后降至初始值的近50%，随后几个月进一步下降，并在研究剩余时间保持下降。
Serial chromosome and biochemical studies were carried out in 11 subjects before and during initial occupational exposure to moderate quantities of lead fumes in a storage battery plant. The rate of abnormal metaphases, mostly with chromatid and one-break chromosome aberrations, was approximately doubled after one month of work; it further increased after two months of work; remained in this range up to seven months of exposure; and then tended to decrease somewhat. Blood lead levels increased progressively in the first few months, then reached a steady state. Urinary lead and coproporphyrin levels increased sharply after one month of work, while urinary delta-aminolevulinic acid (ALA) levels increased moderately. The ALA dehydratase (ALAD) activity of red blood cells (RBCs) was reduced to almost 50% of the initial values after one month, decreased further in subsequent months, and remained decreased through the remainder of the study.