Sexual dysfunction and its impact on quality of life in Chinese patients with schizophrenia treated in primary care
Sexual dysfunction and its impact on quality of life in Chinese patients with schizophrenia treated in primary care
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DOI：
10.1016/j.comppsych.2015.11.002
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发表时间：
2016-02-01
影响因子：
7.3
通讯作者：
Xiang, Yu-Tao
中科院分区：
文献类型：
--
作者：
Hou, Cai-Lan;Zang, Yu;Xiang, Yu-Tao
目的：精神分裂症患者性功能障碍较为常见。在中国，临床稳定的精神分裂症患者的维持治疗通常由初级保健医生提供。从未研究过该患者人群中与疾病或治疗相关的性功能障碍。本研究描述了中国初级保健中接受治疗的精神分裂症患者性功能障碍的患病率、相关因素及其对生活质量（QOL）的影响。方法：研究样本为在中国随机选择的22个初级保健服务机构接受治疗的607名精神分裂症患者。患者的社会人口统计学和临床特征，包括性功能和QOL记录使用标准化的协议和datacollection.Results：性功能障碍存在于69.9%的所有患者，男性60.7%，女性80.6%。多因素Logistic回归分析显示，女性、单身、年龄大、使用第一代抗精神病药是性功能障碍发生的独立危险因素，占总方差的23.5%（P < 0.001）。出乎意料的是，性功能障碍与较低的生活质量无关。结论：中国大多数初级保健治疗的精神分裂症患者性功能障碍的发生率很高。鉴于其对社会适应、生活质量和治疗依从性的负面影响，应努力解决这一患者人群的性功能障碍。(C)2015 Elsevier Inc. All rights reserved.
Purpose: Sexual dysfunction in schizophrenia patients is common. In China, maintenance treatment for clinically stable patients with schizophrenia is usually provided by primary care physicians. Illness- or treatment-related sexual dysfunction in this patient population has been never studied. This study describes the prevalence and correlates of sexual dysfunction and its impact on quality of life (QOL) in patients with schizophrenia treated in primary care in China.Method: A total of 607 patients with schizophrenia treated in 22 randomly selected primary care services in China formed the study sample. Patients' socio-demographic and clinical characteristics including sexual function and QOL were recorded using a standardized protocol and data collection.Results: Sexual dysfunction was present in 69.9% of all patients; 60.7% in males and 80.6% in females. Multiple logistic regression analysis revealed that female gender, being single, older age and use of first-generation antipsychotics were independently and significantly associated with more sexual dysfunction accounting for 23.5% of its variance (P < 0.001). Unexpectedly, sexual dysfunction was not associated with lower QOL.Conclusions: High rate of sexual dysfunction was reported in the majority of patients with schizophrenia treated in primary care in China. Given its negative impact on social adjustment, QOL and treatment adherence, efforts should be made to address sexual dysfunction in this patient population. (C) 2015 Elsevier Inc. All rights reserved.