Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers
Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers
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DOI：
10.1371/journal.pcbi.1007229
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发表时间：
2019-07-01
影响因子：
4.3
通讯作者：
Li, Jonathan Z.
中科院分区：
文献类型：
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作者：
Conway, Jessica M.;Perelson, Alan S.;Li, Jonathan Z.
抗逆转录病毒疗法 (ART) 可以有效控制 HIV 感染，抑制 HIV 病毒载量。暂停治疗后，病毒载量反弹至治疗前的高水平。然而，反弹速度存在显着的异质性，有些反弹发生在几天、几周甚至几年内。我们提出了一个随机数学模型来深入了解这些治疗后动态，特别是描述短期病毒反弹的动态（
Antiretroviral therapy (ART) effectively controls HIV infection, suppressing HIV viral loads. Suspension of therapy is followed by rebound of viral loads to high, pre-therapy levels. However, there is significant heterogeneity in speed of rebound, with some rebounds occurring within days, weeks, or sometimes years. We present a stochastic mathematical model to gain insight into these post-treatment dynamics, specifically characterizing the dynamics of short term viral rebounds (