Prevalence and treatment conditions for hypertension and dyslipidaemia complicated with systemic lupus erythematosus: A multi-centre cross-sectional study
Prevalence and treatment conditions for hypertension and dyslipidaemia complicated with systemic lupus erythematosus: A multi-centre cross-sectional study
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DOI：
10.1177/09612033211006790
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发表时间：
2021-04-01
期刊：
影响因子：
2.6
通讯作者：
Sada, Ken-ei
中科院分区：
文献类型：
--
作者：
Saito, Mayu;Yajima, Nobuyuki;Sada, Ken-ei
目的探讨高血压和血脂异常合并系统性红斑狼疮（SLE）的患病率及实际治疗情况。方法采用横断面研究。我们建立了全国性机构狼疮登记处（LUNA），这是一个日本狼疮患者的多中心队列研究。2016年2月至2018年7月，在LUNA中登记了597例SLE患者。我们评估了高血压和血脂异常的发生率，并通过logistic回归分析了高血压和血脂异常的危险因素。结果共纳入597例患者。中位年龄44岁，88.0%为女性。92.9%的患者使用泼尼松龙。高血压和血脂异常患病率分别为43.9%和54.7%。在接受高血压药物治疗的患者中，24.7%的患者表现为控制不足（收缩压>140 mmHg或舒张压>90 mmHg），而在接受高脂血症药物治疗的患者中，48.1%的患者表现为控制不足（低密度脂蛋白胆固醇>140 mg/dL或甘油三酯>150 mg/dL）。高血压的危险因素是年龄、身体质量指数（BMI）、病程、既往泼尼松龙最大剂量和肾脏受累，而血脂异常的危险因素是年龄和身体质量指数。结论约半数患者存在高血压或血脂异常，且有相当一部分患者用药后控制不佳。我们的数据表明，医生应该治疗SLE活动性及其并发症，特别是动脉粥样硬化的常见危险因素。
ObjectiveThis study aimed to assess the prevalence and actual treatment conditions for hypertension and dyslipidaemia complicated with systemic lupus erythematosus (SLE).MethodsThis was a cross-sectional study. We established the lupus registry of nationwide institutions (LUNA), a multi-centre cohort of SLE patients in Japan. From February 2016 to July 2018, 597 SLE patients were registered in the LUNA. We evaluated the incidence of hypertension and dyslipidaemia and analysed the risk factors for hypertension and dyslipidaemia by logistic regression analysis.ResultsOverall, 597 patients were enrolled in the study. The median age was 44 years, and 88.0% of the patients were female. Among all the patients, 92.9% used prednisolone. The prevalence of hypertension and dyslipidaemia was 43.9% and 54.7%, respectively. Among the patients receiving medication for hypertension, 24.7% exhibited insufficient control (systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg), and among those receiving medication for hyperlipidaemia, 48.1% showed insufficient control (low-density lipoprotein cholesterol >140 mg/dL or triglyceride >150 mg/dL). The risk factors for hypertension were age, body mass index (BMI), disease duration, past maximum dose of prednisolone, and renal involvement, whereas those for dyslipidaemia were age and BMI.ConclusionAbout half of the patients had hypertension or dyslipidaemia, and a considerable number of cases were poorly controlled despite medication. Our data suggest that physicians should treat SLE activity as well as its complications, especially the common risk factors for atherosclerosis.