The bare necessities of plant K+ channel regulation.
The bare necessities of plant K+ channel regulation.
复制标题
植物K+通道调节的基本要求。
DOI：
10.1093/plphys/kiab266
复制
发表时间：
2021-12-04
期刊：
影响因子：
7.4
通讯作者：
Lefoulon C
中科院分区：
文献类型：
--
作者：
Lefoulon C
虽然植物电压依赖性的K+通道体现了动物和细菌通道中常见的许多特征，但它们的门控仍在挑战机械理解。
钾（K+）通道在植物中发挥了广泛的功能，从矿物营养和渗透平衡到爆炸的膨胀和防护细胞孔径控制。植物K+通道是电压依赖性K+通道或KV通道的超家族的成员，其中包括首先在水果蝇（果蝇Melanogaster）中鉴定出的振荡器通道。在过去的半个世纪中，对KV通道进行了深入研究，并且是植物中电压依赖性通道中最著名的。像动物的KV通道一样，植物KV通道通过通常称为门控的构象机制在毫秒的时间标准上受到调节。现在已经确定了门控的许多方面，但是这些渠道仍然有一些秘密，尤其是在控制门口时。如何实现这种控制尤其重要，因为它具有溶液的实质前景，可以提高生长和用水效率。 KAT1 K+通道的结构的分辨率是结晶的第一个植物的通道，表明许多先前关于通道功能如何重新访问的假设。在这里，我将植物KV通道裸露以了解它们的工作原理，通过电压向门控的方式以及在某些情况下通过K+本身进行门控，以及这些通道的门控如何通过与其他蛋白质伙伴的结合来调节这些通道的门控。植物KV通道的每一个特征对植物生理具有重要意义。
While plant voltage-dependent K+ channels embody many of the characteristics common among animal and bacterial channels, their gating continues to challenge mechanistic understanding. Potassium (K+) channels serve a wide range of functions in plants from mineral nutrition and osmotic balance to turgor generation for cell expansion and guard cell aperture control. Plant K+ channels are members of the superfamily of voltage-dependent K+ channels, or Kv channels, that include the Shaker channels first identified in fruit flies (Drosophila melanogaster). Kv channels have been studied in depth over the past half century and are the best-known of the voltage-dependent channels in plants. Like the Kv channels of animals, the plant Kv channels are regulated over timescales of milliseconds by conformational mechanisms that are commonly referred to as gating. Many aspects of gating are now well established, but these channels still hold some secrets, especially when it comes to the control of gating. How this control is achieved is especially important, as it holds substantial prospects for solutions to plant breeding with improved growth and water use efficiencies. Resolution of the structure for the KAT1 K+ channel, the first channel from plants to be crystallized, shows that many previous assumptions about how the channels function need now to be revisited. Here, I strip the plant Kv channels bare to understand how they work, how they are gated by voltage and, in some cases, by K+ itself, and how the gating of these channels can be regulated by the binding with other protein partners. Each of these features of plant Kv channels has important implications for plant physiology.
登录
查看更多内容
影响因子：
56.9
作者：
Doyle, DA;Cabral, JM;MacKinnon, R
通讯作者：
MacKinnon, R
DOI：
10.1085/jgp.99.4.615
发表时间：
1992-04
期刊：
The Journal of general physiology
影响因子：
--
作者：
Blatt MR
通讯作者：
Blatt MR
影响因子：
6.9
作者：
Amtmann, A;Laurie, S;Sanders, D
通讯作者：
Sanders, D
DOI：
10.1111/tpj.12471
发表时间：
2014-04
期刊：
The Plant journal : for cell and molecular biology
影响因子：
--
作者：
Eisenach C;Papanatsiou M;Hillert EK;Blatt MR
通讯作者：
Blatt MR
影响因子：
3.4
作者：
Dreyer, I;Porée, F;Mueller-Roeber, B
通讯作者：
Mueller-Roeber, B