Heavy charged particles in radiation biology and biophysics
Heavy charged particles in radiation biology and biophysics
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DOI：
10.1088/1367-2630/10/7/075006
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发表时间：
2008-07-28
影响因子：
3.3
通讯作者：
Brahme, A.
中科院分区：
文献类型：
--
作者：
Nikjoo, H.;Uehara, S.;Brahme, A.
电离辐射由于辐射径迹的能量沉积而在哺乳动物细胞中引起各种分子和细胞类型的损伤。一般来说，径迹可分为两类：稀疏电离径迹（如电子径迹）和密集电离径迹（如重离子径迹）。本文讨论了这两种辐射的各个方面和区别以及它们在放射治疗中的疗效。对辐射轨迹的生物物理学研究为从机理上理解最初的物理事件与观察到的生物反应之间的关系提供了许多见解。因此，蒙特卡罗轨道结构技术和程序的发展是至关重要的领域的进步。在本文中，我们报告的最新发展，第一次模拟质子轨道高达200 MeV类似的束流能量在质子放射治疗和空间辐射。离子径迹模型的发展至关重要的是液态水中电子径迹截面的精确模拟。在本文中，我们报告的发展，在液态水中的电子轨道横截面使用一个新的低能量电子精确到近10%的电介质模型下降到100 eV。
Ionizing radiations induce a variety of molecular and cellular types of damage in mammalian cells as a result of energy deposition by the radiation track. In general, tracks are divided into two classes of sparsely ionizing ones such as electron tracks and densely ionizing tracks such as heavy ions. The paper discusses various aspects and differences between the two types of radiations and their efficacies in radiation therapy. Biophysical studies of radiation tracks have provided much of the insight in mechanistic understanding of the relationship between the initial physical events and observed biological responses. Therefore, development of Monte Carlo track-structure techniques and codes are paramount for the progress of the field. In this paper, we report for the first time the latest development for the simulation of proton tracks up to 200 MeV similar to beam energies in proton radiotherapy and space radiation. Vital to the development of the models for ion tracks is the accurate simulation of electron tracks cross sections in liquid water. In this paper, we report the development of electron track cross sections in liquid water using a new dielectric model of low-energy electrons accurate to nearly 10% down to 100 eV.