Diaporisoindoles A-C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic Fungus Diaporthe sp SYSU-HQ3
Diaporisoindoles A-C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic Fungus Diaporthe sp SYSU-HQ3
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Diaporisoindole A-C：来自红树林内生真菌 Diaporthe sp SYSU-HQ3 的三种异戊二烯基异吲哚生物碱衍生物
DOI：
10.1021/acs.orglett.7b02748
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发表时间：
2017-10-20
期刊：
影响因子：
5.2
通讯作者：
She, Zhigang
中科院分区：
文献类型：
--
作者：
Cui, Hui;Lin, Yun;She, Zhigang
Diaporisoindoles A (1) and B (2), two novel isoprenylisoindole alkaloids, and an unusual diisoprenylisoindole dimer diaporisoindole C (3), together with a precursor tenellone C (4) were all isolated from the endophytic fungus Diaporthe sp. SYSU-HQ3. The absolute configurations of 1-4 were elucidated. by spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Diaporisoindole A (1) and tenellone C (4) exhibited inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B with IC50 values of 4.2 and 5.2 mu M.
