NMDA and dopamine interactions in the nucleus accumbens modulate cortical acetylcholine release.
NMDA and dopamine interactions in the nucleus accumbens modulate cortical acetylcholine release.
复制标题
NMDA 和多巴胺在伏隔核中的相互作用调节皮质乙酰胆碱的释放。
DOI：
10.1111/j.1460-9568.2005.04333.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Bruno,JohnP
中科院分区：
文献类型：
--
作者：
Zmarowski,Amy;Sarter,Martin;Bruno,JohnP
The nucleus accumbens (NAC) plays a key role in directing appropriate motor output following the presentation of behaviorally relevant stimuli. As such, we postulate that accumbens efferents also participate in the modulation of neuronal circuits regulating attentional processes directed toward the identification and selection of these stimuli. In this study,N‐methyl‐d‐aspartate (NMDA) and D1 ligands were perfused into the shell region of the NAC of awake rats. Cortical cholinergic transmission, a mediator of attentional processes, was measured via microdialysis probes inserted into the prefrontal cortex (PFC). NMDA perfusions (150 or 250 µm) into NAC resulted in significant increases in acetylcholine (ACh) efflux in PFC (150–200% above baseline levels). Co‐administration of the D1 antagonist SCH‐23390 (150 µm) markedly attenuated (by approx. 70%) ACh efflux following perfusions of 150 µmNMDA but not following 250 µmNMDA, suggesting that D1 receptor activity contributes to the ability of the lower but not the higher concentration of NMDA to increase cortical ACh release. Collectively, these data reveal a positive modulation of NMDA receptors by D1 receptors in NAC that is expressedtrans‐synaptically at the level of cortical transmission. This modulation may underlie the coordinated linking of attentional processes and motor output following exposure to salient and behaviorally relevant stimuli.
