p27 expression as a prognostic factor of breast cancer in Taiwan
p27 expression as a prognostic factor of breast cancer in Taiwan
复制标题
DOI：
10.1016/s0304-3835(99)00084-1
复制
发表时间：
1999-07-01
期刊：
影响因子：
9.7
通讯作者：
Chang, KJ
中科院分区：
文献类型：
--
作者：
Chu, JS;Huang, CS;Chang, KJ
P27(KIPL)是细胞周期蛋白依赖性激酶抑制剂Cip/Kip家族的成员。它与多种细胞周期蛋白/CDK复合体结合，抑制激酶活性，阻断细胞周期。在乳腺癌、结直肠癌、前列腺癌、非小细胞肺癌和食道癌中，p27表达缺失或降低是预后不良的重要预测因素。应用免疫组织化学方法检测169例乳腺癌组织中p27蛋白的表达，以探讨其生物学意义。高分化(P=0.00025)、雌激素受体阴性(P=0.00004)、孕激素受体阴性(P=0.0038)的乳腺癌与p27蛋白表达降低显著相关。单因素分析显示，p27表达与总生存期呈显著负相关(P=0.0001)。多因素分析显示，p27独立预测总生存期(P=0.0096)。我们的研究显示，p27的表达是台湾地区乳癌的独立预后指标。(C)1999爱思唯尔爱尔兰科学有限公司。保留所有权利。
p27(Kipl) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. It binds to a variety of cyclin/CDK complexes, inhibits kinase activity, and blocks the cell cycle. Absent or reduced p27 expression has been shown to be a significant predictor of poor survival in breast, colorectal, prostate, non-small cell lung and esophagus carcinomas. An immunohistochemical assay was performed on 169 patients with primary breast cancers to evaluate the biologic significance of p27 expression. Decreased p27 expression was significantly associated with high grade (P = 0.00025), negative estrogen receptor (P = 0.00004), and negative progesterone receptor (P = 0.0038) breast cancers. Univariate analysis reveals that p27 expression inversely correlated significantly with overall survival (P = 0.0001). By multivariate analysis, p27 predicted the overall survival independently (P = 0.0096). Our study indicates that p27 expression is an independent prognostic marker of breast cancer in Taiwan. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.