Immunization with autotransporter Vag8 prevents coughing induced by <i>Bordetella pertussis</i> infection in mice
Immunization with autotransporter Vag8 prevents coughing induced by <i>Bordetella pertussis</i> infection in mice
复制标题
使用自转运蛋白 Vag8 进行免疫可预防小鼠由百日咳博德特氏菌感染引起的咳嗽
DOI：
10.1111/1348-0421.13066
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发表时间：
2023
影响因子：
2.6
通讯作者：
Horiguchi Yasuhiko
中科院分区：
文献类型：
--
作者：
Suzuki Koichiro;Hiramatsu Yukihiro;Nishida Takashi;Horiguchi Yasuhiko
百日咳杆菌引起百日咳，其特征是阵发性咳嗽。这种疾病通常通过接种疫苗来预防;然而，尽管疫苗接种覆盖率很高，但全球百日咳病例数量仍在增加。我们以前报道过一种B.百日咳毒力相关基因8（Vag 8）与百日咳毒素和脂寡糖结合引起咳嗽。在这里，我们表明用Vag 8免疫保护小鼠免受B.百日咳感染，并提高了目前的百日咳疫苗的效力，含有百日咳类毒素对咳嗽。我们的研究结果表明，Vag 8可能是预防百日咳咳嗽的疫苗抗原。
Bordetella pertussiscauses pertussis, which is characterized by paroxysmal coughing. This disease is generally prevented through vaccination; however, the number of pertussis cases is increasing worldwide despite high vaccination coverage. We previously reported that an autotransporter ofB. pertussis, virulence‐associated gene 8 (Vag8), causes coughing in combination with pertussis toxin and lipooligosaccharide. Here, we show that immunization with Vag8 protected mice from coughing afterB. pertussisinfection and enhanced the efficacy of a current pertussis vaccine containing pertussis toxoid against the cough. Our findings indicate that Vag8 could be a vaccine antigen to prevent pertussis cough.