Current Understanding of Mitochondrial DNA in Breast Cancer
Current Understanding of Mitochondrial DNA in Breast Cancer
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DOI：
10.1111/j.1524-4741.2009.00767.x
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发表时间：
2009-09-01
期刊：
影响因子：
2.1
通讯作者：
Zhong, Xiao Yan
中科院分区：
文献类型：
--
作者：
Radpour, Ramin;Fan, Alex XiuCheng;Zhong, Xiao Yan
最近线粒体研究的激增是由于对线粒体相关疾病的鉴定以及线粒体在细胞凋亡和衰老中的作用。线粒体DNA（mtDNA）已被认为是参与致癌作用，因为它的高敏感性突变和有限的修复机制相比，核DNA。由于mtDNA缺少内含子，因此大多数突变发生在编码序列中。随后的突变积累可能导致肿瘤形成。由于它们的克隆性质，高拷贝数和高频率突变可以为癌症的检测提供强有力的分子生物标志物。有人认为，mtDNA突变的程度可能有助于癌症预后和/或对某些治疗的反应。在这篇综述文章中，我们的目的是提供一个简短的总结，我们目前的线粒体遗传学和生物学的理解，审查报告在乳腺癌中的mtDNA改变，并提供一些观点，以mtDNA突变的出现，包括其在癌症发展中的功能后果，诊断标准和治疗意义。
The recent surge in mitochondrial research has been driven by the identification of mitochondria-associated diseases and the role of mitochondria in apoptosis and aging. Mitochondrial DNA (mtDNA) has been proposed to be involved in carcinogenesis because of its high susceptibility to mutations and limited repair mechanisms in comparison to nuclear DNA. As mtDNA lacks introns, it has been suggested that most mutations will occur in coding sequences. The subsequent accumulation of mutations may lead to tumor formation. By virtue of their clonal nature, high copy number and high frequent mutations may provide a powerful molecular biomarker for the detection of cancer. It has been suggested that the extent of mtDNA mutations might be useful in the prognosis of cancer outcome and/or the response to certain therapies. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in breast cancer, and offer some perspectives as to the emergence of mtDNA mutations, including their functional consequences in cancer development, diagnostic criteria, and therapeutic implications.