A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access to meta-Arylphenols.
A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access to meta-Arylphenols.
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DOI：
10.1002/asia.201500506
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发表时间：
2016-02-04
期刊：
影响因子：
--
通讯作者：
Larrosa I
中科院分区：
文献类型：
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作者：
Luo J;Preciado S;Araromi SO;Larrosa I
提出了一种通过级联氧化/芳基化/原脱羧序列有效地将水杨醛转化为间芳基化苯酚衍生物的方法。我们证明醛官能团可以用作方便的可去除导向基团来控制 C−H 激活中的位点选择性。醛很容易引入起始材料中，并且在 CH 官能化事件后该基团很容易裂解。
A method that allows salicylaldehydes to be efficiently transformed into meta‐arylated phenol derivatives through a cascade oxidation/arylation/protodecarboxylation sequence is presented. We demonstrate that the aldehyde functional group can be used as a convenient removable directing group to control site selectivity in C−H activation. Aldehydes are easily introduced into the starting materials and the group is readily cleaved after the C−H functionalization event.