Regulation of skeletal development by the Runx family of transcription factors
Regulation of skeletal development by the Runx family of transcription factors
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DOI：
10.1002/jcb.20420
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发表时间：
2005-06-01
影响因子：
4
通讯作者：
Komori, T
中科院分区：
文献类型：
--
作者：
Komori, T
Runx（runt-related protein）家族转录因子在不同的组织和细胞谱系中起着重要的作用。Runx]决定向造血细胞谱系的定型，Runx 2决定向成骨细胞谱系的定型。Cbf β是Runx 1和Runx 2依赖性转录调控所必需的。Runx 2在其靶基因的转录调控中与许多其他转录因子和共调节因子相互作用。Runx 2对于多能间充质细胞向成骨细胞谱系的定向是必需的，并抑制脂肪细胞分化。Runx 2诱导骨基质蛋白的基因表达，同时保持成骨细胞处于未成熟阶段。Runx 2和Runx 3在软骨细胞中具有冗余功能，并且它们对于软骨细胞成熟是必需的。Runx 2直接诱导Indian hedgehog（Ihh）表达并协调软骨细胞的增殖和分化。因此，阐明Runx 2和Runx 3信号通路将揭示骨骼发育的复杂机制。(c)2005年Wiley-Liss，Inc.
The Runx (runt-related protein) family of transcription factors plays importantroles in different tissues and cell lineages. Runx] determines commitment to the hematopoietic cell lineage and Runx2 determines commitment to the osteoblastic lineage. Cbf beta is required for Runx1 - and Runx2-dependent transcriptional regulation. Runx2 interacts with many other transcription factors and co-regulators in the transcriptional regulation of its target genes. Runx2 is essential for the commitment of multipotent mesenchymal cells into the osteoblastic lineage and inhibits adipocyte differentiation. Runx2 induces the gene expression of hone matrix proteins, while keeping the osteoblastic cells in an immature stage. Runx2 and Runx3 have redundant functions in chondrocytes, and they are essential for chondrocyte maturation. Runx2 directly induces Indian hedgehog (Ihh) expression and co-ordinates the proliferation and differentiation of chondrocytes. Therefore, elucidation of the signaling pathways through Runx2 and Runx3 will unravel the complex mechanism of skeletal development. (c) 2005 Wiley-Liss, Inc.