Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: part II.
Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: part II.
复制标题
使用硼苯丙氨酸进行基于正电子发射断层扫描的硼中子捕获疗法治疗高级别神经胶质瘤：第二部分。
作者：
Y. Imahori;Satoshi Ueda;Y. Ohmori;K. Sakae;T. Kusuki;Taishi Kobayashi;M. Takagaki;K. Ono;Tatsuo Ido;R. Fujii
基于正电子发射断层扫描（PET）的氟-18-标记的L-氟硼苯丙氨酸的药代动力学结果，设计了估计肿瘤10 B浓度的方法。在硼中子俘获治疗（BNCT）治疗高级别胶质瘤的临床实践中，大量使用L-硼苯丙氨酸（L-10 B-BPA）-果糖溶液。在此条件下，BNCT应缓慢静脉输注L-10 B-BPA-果糖溶液;因此，靶组织中10 B浓度随时间的变化通过将血浆10 B浓度变化的实际时间过程与包括适当速率常数[K1]的基于PET的权重函数进行卷积来估计（ml/g/min）、k2（min（-1））、k3（min（-1））和k4（min（-1））]。用此方法测定的胶质瘤中10 B浓度与手术标本中的10 B浓度非常接近。这表明氟-18-标记的L-氟硼苯丙氨酸和L-10 B-BPA之间的药代动力学相似。这种方法，使用适当的速率常数，允许确定肿瘤10 B浓度，并广泛适用于临床BNCT，因为平均PET数据足以用于未来的患者，而无需单独的PET研究。
Based on pharmacokinetic findings of fluorine-18-labeled L-fluoroboronophenylalanine by positron emission tomography (PET), methods for estimating tumor 10B concentration were devised. In clinical practice of boron neutron capture therapy (BNCT) for high-grade gliomas, a large amount of L-boronophenylalanine (L-10B-BPA)-fructose solution is used. Under these conditions, a slow i.v. infusion of L-10B-BPA-fructose solution should be performed for BNCT; therefore, the changes over time in 10B concentration in the target tissue were estimated by convoluting the actual time course of changes in plasma 10B concentration with a PET-based weight function including the proper rate constants [K1 (ml/g/min), k2 (min(-1)), k3 (min(-1)), and k4 (min(-1))]. With this method, the estimated values of 10B concentration in gliomas were very close to the 10B levels in surgical specimens. This demonstrated the similarity in pharmacokinetics between fluorine-18-labeled L-fluoroboronophenylalanine and L-10B-BPA. This method, using the appropriate rate constant, permits the determination of tumor 10B concentration and is widely suitable for clinical BNCT, because the averaged PET data are enough to use in future patients without individual PET study.
通过对硼苯丙氨酸硼中子俘获疗法控制大鼠脑内胶质肉瘤。
影响因子：
3.4
作者：
Coderre,JA;Joel,DD;Micca,PL;Nawrocky,MM;Slatkin,DN
通讯作者：
Slatkin,DN