Revised primary structure for human growth hormone.
Revised primary structure for human growth hormone.
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修改了人类生长激素的一级结构。
DOI：
10.1038/newbio230090a0
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
H. Niall
中科院分区：
文献类型：
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作者：
H. Niall
人生长激素（HGH）和人胎盘催乳素（HPL）（也称为人绒毛膜生长催乳素（HCS））之间存在密切的结构相似性，这是几年前根据生理学和免疫学研究1 -3提出的假设，并通过证明两种激素在氨基末端具有高度同源性（前17个残基中有11个相同）得到证实4。其他研究5、6表明，来自HGH和HPL的许多胰蛋白酶肽的氨基酸组成相似，并在羧基末端的一个小区域建立了序列同源性。我已经确定了HPL分子剩余的大部分氨基酸序列。这项工作的全面说明正在编写之中。HPL的氨基末端序列的一部分与HGH 7和绵羊催乳素8的相应区域一起显示在图1中。HPL（残基1-35）和绵羊催乳素（残基10-44）序列的比较提供了很好的同源性证据：35个位置中的12个残基是相同的，另外10个包含通过密码子中高度可接受的点突变相关的氨基酸对9。
A CLOSE structural similarity between human growth hormone (HGH) and human placental lactogen (HPL), also known as human chorionic somatomammotropin (HCS), was postulated several years ago on the basis of physiological and immunological studies1–3 and confirmed by the demonstration of a high degree of homology between the two hormones at the amino-terminus, eleven of the first seventeen residues being identical4. Other studies5, 6 indicated similarities in the amino-acid composition of many of the tryptic peptides derived from HGH and HPL, and established homologies in sequence for a small region at the carboxyl terminus. I have determined much of the remaining amino-acid sequence of the HPL molecule. A full description of this work is in preparation. A portion of the amino-terminal sequence of HPL is shown in Fig. 1, together with corresponding regions of HGH7 and ovine prolactin8. Comparison of the sequences of HPL (residues 1–35) and ovine prolactin (residues 10–44) provides good evidence of homology: residues in twelve of the thirty-five positions are identical and a further ten contain pairs of amino-acids related through highly acceptable point mutations in the codon9.