Experimental Studies on Lymphomatosis of Mice
Experimental Studies on Lymphomatosis of Mice
复制标题
小鼠淋巴瘤病的实验研究
DOI：
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发表时间：
1933
期刊：
影响因子：
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通讯作者：
R. Rathbone
中科院分区：
文献类型：
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作者：
J. Furth;H. R. Seibold;R. Rathbone
小鼠的传染性淋巴瘤病为研究与男性白血病相关的问题提供了一个很好的方法因为人类和这种啮齿动物的疾病本质上是一样的。在这些调查中使用的各种淋巴瘤株的性质差别很大，因此最好描述每一种可传播的菌株。在白血病的传播中，墨菲和他的同事观察到x射线在增强对传染性肿瘤的易感性方面的作用(1)。有必要确定x射线如何影响对淋巴瘤病的易感性以及如何影响由传播引起的疾病。鸡的白血病，像某些鸡的肿瘤一样，是由一种可过滤剂引起的。先前的研究人员认为，在豚鼠（2,3）和小鼠(4)中，淋巴瘤病的传播依赖于活淋巴细胞的转移。这种疾病在这方面类似于哺乳动物的肿瘤。鉴于用无细胞材料证明禽类肿瘤和家禽白血病的传播性存在诸多困难，本文对小鼠淋巴瘤病无细胞传播的可能性进行了深入的研究。
Introduction Transmissible lymphomatosis of mice offers an excellent means of investigating problems connected with leukemia of men because the disease in man and in this rodent is essentially the same. The properties of the various strains of lymphomatosis used in these investigations differ so widely that it is advisable to describe each of the transmissible strains. In the transmission of leukemia advantage was taken of the observations of Murphy and his associates on the effect of x-rays in enhancing the susceptibility to transmissible tumors (1). It has been necessary to determine how x-rays affect susceptibility to lymphomatosis and influence the disease caused by transmission. Leukosis of chickens, like certain chicken tumors, is caused by a filterable agent. Previous workers have believed that trans-mission of lymphomatosis of guinea-pigs (2, 3) and mice (4) is dependent on the transfer of live lymphocytes. The disease in this respect resembles mammalian tumors. In view of the many difficulties of demonstrating the transmissibility of avian tumors and leukosis of fowls by cell-free material, the possibility of cell-free transmission of lymphomatosis of mice was thoroughly reinvestigated.