Neural correlates of evidence accumulation during value-based decisions revealed via simultaneous EEG-fMRI.
Neural correlates of evidence accumulation during value-based decisions revealed via simultaneous EEG-fMRI.
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DOI：
10.1038/ncomms15808
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发表时间：
2017-06-09
影响因子：
16.6
通讯作者：
Philiastides MG
中科院分区：
文献类型：
--
作者：
Pisauro MA;Fouragnan E;Retzler C;Philiastides MG
目前的计算解释表明，在简单的二元选择中，人类在做出决定之前会积累有利于不同选择的证据。在顶叶和前额叶皮层的感知决策过程中，已经发现了这种积累活动的神经相关性;然而，在基于价值的选择中，这种活动的来源仍然未知。在这里，我们同时使用EEG-fMRI和计算建模来识别反映积累过程的EEG信号，并证明这些信号中的试验内和试验间变异性解释了后内侧额叶皮层的fMRI反应。与其在做出决定之前整合证据的作用相一致，该区域还表现出与腹内侧前额叶皮层和纹状体的任务依赖性耦合，已知这些大脑区域编码决策选择的主观价值。这些结果进一步支持了人类基于价值的决策过程中证据积累过程的命题，并暗示后内侧额叶皮层在这一过程中。顶叶和前额叶皮层收集信息以做出感知决策，但不知道是否同样适用于基于价值的选择。在这里，作者使用同步EEG-fMRI和建模来表明，在基于价值和奖励的决策过程中，这些证据是在后内侧额叶皮层中积累的。
Current computational accounts posit that, in simple binary choices, humans accumulate evidence in favour of the different alternatives before committing to a decision. Neural correlates of this accumulating activity have been found during perceptual decisions in parietal and prefrontal cortex; however the source of such activity in value-based choices remains unknown. Here we use simultaneous EEG–fMRI and computational modelling to identify EEG signals reflecting an accumulation process and demonstrate that the within- and across-trial variability in these signals explains fMRI responses in posterior-medial frontal cortex. Consistent with its role in integrating the evidence prior to reaching a decision, this region also exhibits task-dependent coupling with the ventromedial prefrontal cortex and the striatum, brain areas known to encode the subjective value of the decision alternatives. These results further endorse the proposition of an evidence accumulation process during value-based decisions in humans and implicate the posterior-medial frontal cortex in this process. Parietal and prefrontal cortices gather information to make perceptual decisions, but it is not known if the same is true for value-based choices. Here, authors use simultaneous EEG-fMRI and modelling to show that during value- and reward-based decisions this evidence is accumulated in the posterior medial frontal cortex.