Projections to the alimentary canal from the dopaminergic neurons in the dorsal motor nucleus of the vagus of the rat
Projections to the alimentary canal from the dopaminergic neurons in the dorsal motor nucleus of the vagus of the rat
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DOI：
10.1016/j.autneu.2005.07.009
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发表时间：
2005-12-30
影响因子：
2.7
通讯作者：
Yamamura, T
中科院分区：
文献类型：
--
作者：
Tsukamoto, K;Hayakawa, T;Yamamura, T
消化道的运动不仅受含有乙酰胆碱或肾上腺素的神经元的调节，也受非肾上腺素能的非胆碱能神经元的调节。迷走神经背侧运动核（DMV）内有许多含有多巴胺的神经元。在将酪氨酸羟化酶（TH）和逆行示踪剂霍乱毒素亚基b注射到膈下食道、贲门、十二指肠、空肠和升结肠后，我们用免疫组化双标记法检测了这些多巴胺能神经元向消化道的投射。几乎所有的双标记神经元都出现在DMV尾侧到后脑区的一半区域。在DMV尾侧，约58%的th免疫反应神经元投射到贲门，约36%投射到幽门，约28%投射到膈下食道。只有少数th免疫反应神经元投射到十二指肠、空肠或升结肠。总体而言，DMV中投射到消化道的神经元中只有不到10%表现出th样免疫活性。这些结果提示DMV中的一些多巴胺能神经元可能调节胃和膈下食道的活动。(c) 2005 Elsevier B.V.版权所有
The motility of the alimentary canal is regulated not only by neurons that contain acetylcholine or adrenaline, but also by nonadrenergic noncholinergic neurons. There are many neurons containing dopamine in the dorsal motor nucleus of the vagus (DMV). We examined the projections of these dopaminergic neurons to the alimentary canal with double-labeling immunohistochemistry for tyrosine hydroxylase (TH) and the retrograde tracer cholera toxin subunit b following its injection into the subdiaphragmatic esophagus, the cardia, the pylorus, the duodenum, the jejunum, and the ascending colon. Almost all double-labeled neurons were found in the half of the DMV caudal to the area postrema. In the caudal half of the DMV, about 58% of the TH-immunoreactive neurons projected to the cardia, about 36% projected to the pylorus, and about 28% projected to the subdiaphragmatic esophagus. Only a few TH-immunoreactive neurons projected to the duodenum, the jejunum, or the ascending colon. As a whole, less than 10% of the neurons in the DMV that projected to the alimentary canal showed TH-like immumoreactivity. These results suggest that some of the dopammergic neurons in the DMV might regulate the activities of the stomach and the subdiaphragmatic esophagus. (c) 2005 Elsevier B.V. All rights reserved.