Histologic effect of a variable pulsed Er:YAG laser
Histologic effect of a variable pulsed Er:YAG laser
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DOI：
10.1046/j.1524-4725.2000.00035.x
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发表时间：
2000-08-01
影响因子：
2.4
通讯作者：
Goldberg, DJ
中科院分区：
文献类型：
--
作者：
Pozner, JM;Goldberg, DJ
背景二氧化碳（CO2）激光用于激光表面修复会产生显著的热损伤。短脉冲Er：YAG激光器提供了对消融深度的显著控制，并具有最小的热损伤。较新的组合短脉冲/长脉冲Er：YAG激光器提供了精确控制烧蚀深度和所选热损伤程度的潜力。确定消融性短脉冲Er：YAG激光和/或热损伤性长脉冲Er：YAG激光的组织学效应与此类机器的触摸面板上选择的结果之间的相关性。对腹壁成形术标本进行原位激光照射。在机器上选择不同的消融深度和/或热效应。对组织进行激光照射，组织学分析，并由盲法皮肤病理学家分析消融/热损伤深度。短脉冲Er：YAG激光表面置换术后的激光消融后组织学深度与机器上选择的深度相关性良好。然而，当选择较长的热损伤Er：YAG激光脉冲时，所选的消融和/或热损伤深度仅在第一次通过时显示组织学相关性。重复通过，使用可变脉冲宽度，消融的组织学深度和残余热损伤与机器上的设置不匹配，结论。双模式Er：YAG激光器可对所有短脉冲Er：YAG激光器的消融深度进行组织学控制。此外，当这种系统与更长的Er：YAG激光脉冲一起使用时，可以观察到CO2激光所需的组织学热效应。在所有选定的短脉冲Er：YAG激光参数水平下，所选激光参数与组织学结果之间存在良好的相关性。在单独使用较长脉冲热损伤Er：YAG激光或与较短脉冲消融Er：YAG激光组合首次通过后，所选激光参数与组织学结果之间存在良好的相关性。然而，在这些模式下的后续激光通过显示所选激光参数与组织学效应之间的相关性较差，当这种激光用于临床时，这些发现具有重要意义。
BACKGROUND. Carbon dioxide (CO2) lasers used for laser resurfacing produce significant thermal damage. Short-pulsed Er: YAG lasers provide significant control over depth of ablation with minimal thermal damage. Newer combined short-pulsed/ long-pulsed Er:YAG lasers offer the potential for both precise control over depth of ablation and degree of chosen thermal damage.OBJECTIVE. TO determine the correlation between the histologic effects of an ablative short-pulsed Er:YAG laser and/or a thermally damaging longer-pulsed Er:YAG laser and the findings chosen on the touch panel of such a machine.METHODS. In situ lasing of abdominoplasty specimens was undertaken. Various depths of ablation and/or thermal effect were chosen on the machine, The tissue was laser irradiated, histologically analyzed, and ablation/thermal depths of damage were analyzed by a blinded dermatopathologist.RESULTS. Postlaser histologic depths of ablation after shortpulsed Er:YAG laser resurfacing correlated well with those chosen on the machine. However, when a longer, thermally damaging Er:YAG laser pulse was chosen, chosen ablative and/or thermal depths of damage showed histologic correlation only for the first pass. With repeated passes, using the variable pulse width, the histologic depth of ablation and residual thermal damage do not match the settings on the machine,CONCLUSION. A dual-mode Er:YAG laser provides the histologic control over depth of ablation seen with all short-pulsed Er:YAG lasers. In addition, the histologic thermal effect desired from CO2 lasers could be observed when such a system is used with longer Er:YAG laser pulses. Good correlation between chosen laser parameters and histologic findings are seen with all chosen levels of short-pulsed Er:YAG laser parameters. Good correlation is seen between the chosen laser parameters and histologic findings after a first pass of either a longer pulsed thermal damaging Er:YAG laser alone or in combination with a shorter pulsed ablative Er:YAG laser. However, subsequent laser passes in these modes showed poor correlation between the chosen laser parameters and histologic effect, Such findings have important implications when such a laser is used clinically.