HIV Infection Is Associated with a Preferential Decline in Less-Differentiated CD56dim CD16+ NK Cells
HIV Infection Is Associated with a Preferential Decline in Less-Differentiated CD56dim CD16+ NK Cells
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DOI：
10.1128/jvi.01675-09
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发表时间：
2010-01-15
影响因子：
5.4
通讯作者：
Meyer-Olson, Dirk
中科院分区：
文献类型：
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作者：
Hong, Henoch S.;Eberhard, Johanna M.;Meyer-Olson, Dirk
HIV-1感染的特征是CD56(Dim)CD16(+)NK细胞的丧失和各种淋巴细胞亚群的终末分化增加。在慢性HIV感染的CD56dim CD16(+)NK细胞上，CD57(+)和CD57(Dim)细胞减少，但CD57(Right)细胞不减少。CD57表达的增加与杀伤免疫球蛋白样受体(KIRS)和颗粒酶B表达细胞的增加密切相关，而CD27(+)、HLA-DR+、Ki-67(+)和CD107a表达的细胞百分比减少。我们的数据表明，HIV导致分化较少的细胞减少，提示CD57是NK细胞终末分化的有用标记物。
HIV-1 infection is characterized by loss of CD56(dim) CD16(+) NK cells and increased terminal differentiation on various lymphocyte subsets. We identified a decrease of CD57(+) and CD57(dim) cells but not of CD57(bright) cells on CD56dim CD16(+) NK cells in chronic HIV infection. Increasing CD57 expression was strongly associated with increasing frequencies of killer immunoglobulin-like receptors (KIRs) and granzyme B-expressing cells but decreasing percentages of cells expressing CD27(+), HLA-DR+, Ki-67(+), and CD107a. Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells.