Nicotine-induced place conditioning and locomotor activity in an adolescent animal model of attention deficit/hyperactivity disorder (ADHD).
Nicotine-induced place conditioning and locomotor activity in an adolescent animal model of attention deficit/hyperactivity disorder (ADHD).
复制标题
注意力缺陷/多动障碍（ADHD）青少年动物模型中尼古丁诱导的位置调节和运动活动。
DOI：
10.1016/j.bbr.2015.05.031
复制
发表时间：
2015
影响因子：
2.7
通讯作者：
Sanabria,Federico
中科院分区：
文献类型：
--
作者：
Watterson,Elizabeth;Daniels,CarterW;Watterson,LucasR;Mazur,GabrielJ;Brackney,RyanJ;Olive,MFoster;Sanabria,Federico
注意缺陷/多动障碍（ADHD）是烟草使用和依赖的一个危险因素。本研究考察了青少年ADHD模型——自发性高血压大鼠（SHR）对尼古丁的反应性。在尼古丁剂量（0.0、0.1、0.3和0.6 mg/kg）范围内，使用条件位置偏好（CPP）程序评估SHR和Wistar Kyoto （WKY）对照品系尼古丁诱导的运动和条件奖励。在条件反射之前，SHRs比WKY大鼠更活跃，更少偏向于CPP室的一侧。调节后，SHRs在最高尼古丁剂量（0.6 mg/kg）下发生CPP，而WKYs在任何尼古丁剂量下均未发生CPP。在整个条件反射试验中，尼古丁配对组的shr表现出比盐配对组更大的运动活性。在尼古丁配对的隔间中接受尼古丁（0.1,0.3,0.6 mg/kg）的SHRs在条件反射试验之间显示出运动活动的增加。尼古丁对WKY运动活动无显著影响。这些发现表明，SHR菌株是研究adhd相关尼古丁使用和依赖的合适模型，但突出了WKY对照菌株和CPP程序在建模adhd相关尼古丁奖励方面的潜在局限性。
Attention deficit/hyperactivity disorder (ADHD) is a risk factor for tobacco use and dependence. This study examines the responsiveness to nicotine of an adolescent model of ADHD, the spontaneously hypertensive rat (SHR). The conditioned place preference (CPP) procedure was used to assess nicotine-induced locomotion and conditioned reward in SHR and the Wistar Kyoto (WKY) control strain over a range of nicotine doses (0.0, 0.1, 0.3 and 0.6 mg/kg). Prior to conditioning, SHRs were more active and less biased toward one side of the CPP chamber than WKY rats. Following conditioning, SHRs developed CPP to the highest dose of nicotine (0.6 mg/kg), whereas WKYs did not develop CPP to any nicotine dose tested. During conditioning, SHRs displayed greater locomotor activity in the nicotine-paired compartment than in the saline-paired compartment across conditioning trials. SHRs that received nicotine (0.1, 0.3, 0.6 mg/kg) in the nicotine-paired compartment showed an increase in locomotor activity between conditioning trials. Nicotine did not significantly affect WKY locomotor activity. These findings suggest that the SHR strain is a suitable model for studying ADHD-related nicotine use and dependence, but highlights potential limitations of the WKY control strain and the CPP procedure for modeling ADHD-related nicotine reward.