The West Nile Virus outbreak of 1999 in New York: The flushing hospital experience
The West Nile Virus outbreak of 1999 in New York: The flushing hospital experience
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DOI：
10.1086/313737
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发表时间：
2000-03-01
影响因子：
11.8
通讯作者：
Sampson, BA
中科院分区：
文献类型：
--
作者：
Asnis, DS;Conetta, R;Sampson, BA
西尼罗河病毒（WNV）是一种蚊媒黄病毒，已知在非洲，中东和亚洲西南部引起人类感染。它在澳大利亚也被隔离，偶尔在欧洲也被隔离，但从未在美洲被隔离。临床特征包括急性发热、严重肌痛、头痛、结膜炎、淋巴结病和玫瑰色皮疹。很少见到脑炎或脑膜炎。在1999年8月期间，纽约市同一家医院的重症监护室收治了5名发热、意识模糊和虚弱的患者。最终，5名患者中有4名出现弛缓性麻痹，需要辅助治疗。此后不久，三名病情较轻的患者出现。在纽约市和纽约州卫生部门以及疾病控制和预防中心的协助下，这些病例被记录为该大陆上第一例西尼罗河病毒感染病例。
West Nile Virus (WNV) is a mosquito-borne flavivirus, which has been known to cause human infection in Africa, the Middle East, and southwestern Asia. It has also been isolated in Australia and sporadically in Europe but never in the Americas. Clinical features include acute fever, severe myalgias, headache, conjunctivitis, lymphadenopathy, and a roseolar rash. Rarely is encephalitis or meningitis seen. During the month of August 1999, a cluster of 5 patients with fever, confusion, and weakness were admitted to the intensive care unit of the same hospital in New York City. Ultimately 4 of the 5 developed flaccid paralysis and required ventilatory support. Three patients with less-severe cases presented shortly thereafter. With the assistance of the New York City and New York State health departments and the Centers for Disease Control and Prevention, these were documented as the first cases of WNV infection on this continent.