Biomimetic radical polymerization via cooperative assembly of segregating templates
Biomimetic radical polymerization via cooperative assembly of segregating templates
复制标题
DOI：
10.1038/nchem.1331
复制
发表时间：
2012-06-01
期刊：
影响因子：
21.8
通讯作者：
O'Reilly, Rachel K.
中科院分区：
文献类型：
--
作者：
McHale, Ronan;Patterson, Joseph P.;O'Reilly, Rachel K.
隔离和模板方法已经经过数十亿年的进化磨练，可以指导许多复杂的生物过程。自然界使用分离来改善生化控制，通过将反应物组织到定义的，良好调控的环境中，遗传信息的传递是模板的主要功能。核糖体，其中信使RNA被翻译成多肽，结合两种技术，以允许理想的生物聚合物合成。本文提出了一种仿生分离/模板合成自由基聚合的方法。在低分子量的互补嵌段共聚物模板存在下，含核碱基的乙烯基单体的聚合产生高分子量（M-w高达约400，000 g mol（-1））、极低的多分散性（
Segregation and templating approaches have been honed by billions of years of evolution to direct many complex biological processes. Nature uses segregation to improve biochemical control by organizing reactants into defined, well-regulated environments, and the transfer of genetic information is a primary function of templating. The ribosome, wherein messenger RNA is translated into polypeptides, combines both techniques to allow for ideal biopolymer syntheses. Herein is presented a biomimetic segregation/templating approach to synthetic radical polymerization. Polymerization of a nucleobase-containing vinyl monomer in the presence of a complementary block copolymer template of low molecular weight yields high molecular weight (M-w up to similar to 400,000 g mol(-1)), extremely low polydispersity (