HEROIN SELF-ADMINISTRATION BY RATS - INFLUENCE OF DOSE AND PHYSICAL-DEPENDENCE
HEROIN SELF-ADMINISTRATION BY RATS - INFLUENCE OF DOSE AND PHYSICAL-DEPENDENCE
复制标题
DOI：
10.1016/0091-3057(89)90074-9
复制
发表时间：
1989-04-01
影响因子：
3.6
通讯作者：
KALANT, H
中科院分区：
文献类型：
--
作者：
DAI, S;CORRIGALL, WA;KALANT, H
本实验观察了大鼠静脉注射不同浓度的海洛因后，其压杆行为的增强以及由此产生的身体依赖性。此外，阿片依赖的影响，以及其消失后戒断，对海洛因自我管理进行了调查。结果发现，以0.03 mg/kg/输注静脉自我给药Herion可维持自我给药行为，而不会产生身体依赖性。每届会议的总反应随着海洛因的单位剂量的增加而减少，而自我管理的药物总量与单位剂量直接相关。在以0.1、0.3或0.6 mg/kg/输注剂量自我给予Herion后，观察到纳洛酮注射后戒断体征和体重减轻百分比显著增加。在阿片依赖和后依赖动物中，发现0.03 mg/kg/输注的海洛因摄入量显著增加，而0.1、0.3或0.6 mg/kg/输注的海洛因摄入量则没有显著增加。这些发现支持先前使用0.03 mg/kg/输注作为说明海洛因强化作用而不受身体依赖性影响的合适剂量。
Lever-pressing behavior reinforced by intravenous infusion of various concentrations of heroin, the consequent development of physical dependence, were examined in rats. In addition, the influence of opiate dependence, and of its disappearance following withdrawal, on heroin self-administration were investigated. It was found that intravenous self-administration of herion at 0.03 mg/kg/infusion maintained self-administration behavior without producing physical dependence. Total responses per session decreased with increasing unit dose of heroin, whereas the total amount of drug self-administered was directly related to unit dose. Significantly greater numbers of withdrawal signs and percentage body weight losses in response to naloxone injections were observed following self-administration of herion at 0.1, 0.3 or 0.6 mg/kg/infusion. Intake of heroin at 0.03 mg/kg/infusion, but not at 0.1, 0.3 or 0.6 mg/kg/infusion, was found to increase significantly in opiate-dependent and postdependent animals. These findings support the previous use of 0.03 mg/kg/infusion as a suitable dose for illustrating the reinforcing effect of heroin without the influence of physical dependence.