Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing.
Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing.
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DOI：
10.1126/scitranslmed.3004129
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发表时间：
2012-08-22
影响因子：
17.1
通讯作者：
Segre JA
中科院分区：
文献类型：
--
作者：
Snitkin ES;Zelazny AM;Thomas PJ;Stock F;NISC Comparative Sequencing Program Group;Henderson DK;Palmore TN;Segre JA
革兰氏阴性细菌肺炎克雷伯氏菌是医院感染的主要原因，主要发生在免疫功能低下的患者中。对碳青霉烯类耐药菌株的出现使得治疗选择很少，使得感染控制至关重要。2011年，美国国立卫生研究院临床中心爆发了耐碳青霉烯类的克雷伯菌。肺炎感染了18名患者，其中11人死亡。对K.肺炎分离株，以深入了解为什么疫情进展，尽管早期实施感染控制程序。综合基因组和流行病学分析将此次疫情追溯到一名患者的三次独立传播，该患者在下一个病例出现临床症状前3周出院。额外的基因组比较为意外的传播途径提供了证据，随后对流行病学数据的挖掘指出了这些传播的可能解释。我们的分析表明，基因组和流行病学数据的整合可以产生可操作的见解，并促进医院内传播的控制。
The Gram-negative bacteria Klebsiella pneumoniae is a major cause of nosocomial infections, primarily among immunocompromised patients. The emergence of strains resistant to carbapenems has left few treatment options, making infection containment critical. In 2011, the U.S. National Institutes of Health Clinical Center experienced an outbreak of carbapenem-resistant K. pneumoniae that affected 18 patients, 11 of whom died. Whole-genome sequencing was performed on K. pneumoniae isolates to gain insight into why the outbreak progressed despite early implementation of infection control procedures. Integrated genomic and epidemiological analysis traced the outbreak to three independent transmissions from a single patient who was discharged 3 weeks before the next case became clinically apparent. Additional genomic comparisons provided evidence for unexpected transmission routes, with subsequent mining of epidemiological data pointing to possible explanations for these transmissions. Our analysis demonstrates that integration of genomic and epidemiological data can yield actionable insights and facilitate the control of nosocomial transmission.
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影响因子：
30.8
作者：
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影响因子：
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作者：
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通讯作者：
Balloux, F.
影响因子：
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通讯作者：
Scocchi, Marco
DOI：
10.1126/science.1182395
发表时间：
2010-01-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Bentley SD