Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers
Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers
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DOI：
10.1016/j.vetmic.2007.10.006
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发表时间：
2008-04-30
影响因子：
3.3
通讯作者：
Weese, J. S.
中科院分区：
文献类型：
--
作者：
Khanna, T.;Friendship, R.;Weese, J. S.
最近在猪和与猪一起工作的人中发现了耐甲氧西林金黄色葡萄球菌（MRSA）定植，这引起了人们对猪作为MRSA人类感染宿主的作用的担忧。本研究的目的是评价加拿大安大略猪和养猪户中MRSA定植的流行率，并描述MRSA菌株的特征。从20个猪场的3个不同年龄组的285头猪中采集鼻拭子和直肠拭子。从农场人员中采集鼻拭子，并进行简短的问卷调查。农场中NIRSA定植的患病率为45%（9/20），而猪中的患病率为24.9%（71/285）。不同年龄组间MRSA定植率无差异。MRSA在养猪户中的定植率为20%（5/25）。农场猪和人中MRSA的存在之间存在相关性（P值= 0.001）。spa分型结果显示，猪和人中的优势菌株为eGenomics spa 539型（Ridom t034，克隆复合体398），占分离株的59.2%，并已在欧洲猪中报告。在猪和猪工作人员中也发现了一种常见的人类流行性克隆CMRSA-2（USA 100，克隆复合体5）。在所有5个有定植人的农场的猪和猪工作人员中发现了不可区分的菌株。这项研究表明，MRSA是常见的猪在安大略，加拿大，并提供了进一步的支持，猪和人之间的MRSA传播的关注。(C)2007 Elsevier B. V.保留所有权利。
Methicillin resistant Staphylococcus aureus (MRSA) colonization has recently been identified in pigs and people that work with pigs, raising concerns about the role of pigs as reservoirs of MRSA for human infection. The objectives of this study were to evaluate the prevalence of MRSA colonization in pigs and pig farmers in Ontario, Canada and to characterize MRSA strains. Nasal and rectal swabs were collected from 285 pigs from three different age groups from 20 pig farms. Nasal swabs were collected from farm personnel and a brief questionnaire was also administered. The prevalence of NIRSA colonization in farms was 45% (9/20) whereas the prevalence in pigs was 24.9% (71/285). There was no difference in MRSA colonization between age groups. The prevalence of MRSA colonization in pig farmers was 20% (5/25). There was a correlation between the presence of MRSA in pigs and humans on farms (P value = 0.001). The results of spa typing revealed the predominant strain in pigs and humans was eGenomics spa type 539 (Ridom t034, clonal complex 398) which accounted for 59.2% of isolates and has been reported in pigs in Europe. A common human epidemic clone, CMRSA-2 (USA100, clonal complex 5) was also found in both pigs and pig personnel. Indistinguishable strains were found in pigs and pig personnel on all five farms with a colonized human. This study demonstrates that MRSA is common in pigs in Ontario, Canada, and provides further support to concerns about transmission of MRSA between pigs and humans. (C) 2007 Elsevier B.V. All rights reserved.