Maternal immunity enhances Mycoplasma hyopneumoniae vaccination induced cell-mediated immune responses in piglets
Maternal immunity enhances Mycoplasma hyopneumoniae vaccination induced cell-mediated immune responses in piglets
复制标题
DOI：
10.1186/1746-6148-10-124
复制
发表时间：
2014-06-05
影响因子：
2.6
通讯作者：
Molitor, Thomas W.
中科院分区：
文献类型：
--
作者：
Bandrick, Meggan;Theis, Kara;Molitor, Thomas W.
背景：被动获得母源性免疫(MDI)是一把双刃剑。母源性抗体介导的免疫(AMI)和细胞介导的免疫(CMI)是新生儿至关重要的即时防御机制，但MDI可能会干扰新生儿主动免疫的诱导，即被动干预。研究了抗原特异性MDI对疫苗诱导的新生仔猪急性心肌梗死和猪肺炎支原体感染反应的影响。为了确定MDI感染仔猪是否能诱导CMI和AMI反应，在7日龄对母体猪肺炎支原体免疫水平较高和较低的仔猪进行了猪肺炎支原体免疫接种。结果：感染猪肺炎支原体特异性MDI的仔猪未出现疫苗诱导的急性心肌梗死反应；接种猪肺炎支原体特异性MDI后，猪肺炎支原体抗体水平未见升高。然而，感染猪肺炎支原体特异性CMI的仔猪在接种疫苗后出现了初级(抗原特异性淋巴增殖)和继发性(DTH)猪肺炎支原体特异性CMI反应。结论：在本研究中，新生猪肺炎支原体特异性CMI不受MDI被动干预。此外，似乎母源和内源性CMI都有助于面对MDI接种疫苗的仔猪产生猪肺炎支原体特异性CMI反应。
Background: Passively acquired maternal derived immunity (MDI) is a double-edged sword. Maternal derived antibody-mediated immunity (AMI) and cell-mediated immunity (CMI) are critical immediate defenses for the neonate; however, MDI may interfere with the induction of active immunity in the neonate, i.e. passive interference. The effect of antigen-specific MDI on vaccine-induced AMI and CMI responses to Mycoplasma hyopneumoniae (M. hyopneumoniae) was assessed in neonatal piglets. To determine whether CMI and AMI responses could be induced in piglets with MDI, piglets with high and low levels of maternal M. hyopneumoniae-specific immunity were vaccinated against M. hyopneumoniae at 7 d of age. Piglet M. hyopneumoniae-specific antibody, lymphoproliferation, and delayed type hypersensitivity (DTH) responses were measured 7 d and 14 d post vaccination.Results: Piglets with M. hyopneumoniae-specific MDI failed to show vaccine-induced AMI responses; there was no rise in M. hyopneumoniae antibody levels following vaccination of piglets in the presence of M. hyopneumoniae-specific MDI. However, piglets with M. hyopneumoniae-specific MDI had primary (antigen-specific lymphoproliferation) and secondary (DTH) M. hyopneumoniae-specific CMI responses following vaccination.Conclusions: In this study neonatal M. hyopneumoniae-specific CMI was not subject to passive interference by MDI. Further, it appears that both maternal derived and endogenous CMI contribute to M. hyopneumoniae-specific CMI responses in piglets vaccinated in the face of MDI.