Low Glucose Uncouples Hexokinase1-Dependent Sugar Signaling from Stress and Defense Hormone Abscisic Acid and C2H4 Responses in Arabidopsis
Low Glucose Uncouples Hexokinase1-Dependent Sugar Signaling from Stress and Defense Hormone Abscisic Acid and C2H4 Responses in Arabidopsis
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DOI：
10.1104/pp.109.148957
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发表时间：
2010-03-01
期刊：
影响因子：
7.4
通讯作者：
Yoo, Sang-Dong
中科院分区：
文献类型：
--
作者：
Cho, Young-Hee;Sheen, Jen;Yoo, Sang-Dong
所有生物体都有各种各样的代谢途径，使它们能够在基本营养素的帮助下自我维持。为了维持代谢物和能量水平的平衡，生物体发展了复杂的传感和信号传导机制，这些机制是对细胞代谢物波动的生理反应的基础。（拟南芥（Arabidopsis thaliana））中，Glc在许多重要的植物发育过程中具有调节作用，如发芽、幼苗发育、根、茎和芽生长、光合作用、碳和氮代谢、开花，和衰老（Rolland等人，2006年）。己糖激酶（HXK）是许多生物中进化上保守的葡萄糖传感器。在植物中，它在Glc代谢以及Glc传感和信号传导中具有双重功能，其通过整合营养、光和激素信号来调节许多生理过程（摩尔等人，2003; Rolland等人，2006年）。HXK 1功能丧失葡萄糖不敏感2 -1（gin 2 -1）和gin 2 -2已经通过基于高Glc（6%）阻遏测定的突变体筛选分离，显示出在幼苗发育的早期阶段抑制子叶扩展、叶绿素积累和芽生长（摩尔等人，2003年）。突变体的生理生化特性表明，HXK 1可以调节生长促进和生长抑制反应，这取决于生长
All living organisms operate a variety of metabolic pathways that enable them to be self-sustainable with basic nutrients. To maintain the balance of metabolite and energy levels, organisms have developed sophisticated sensing and signaling mechanisms that underlie the physiological responses to cell metabolite fluctuations.In plants including Arabidopsis (Arabidopsis thaliana), Glc has a regulatory role in many important plant developmental processes such as germination, seedling development, root, stem, and shoot growth, photosynthesis, carbon and nitrogen metabolism, flowering, and senescence (Rolland et al., 2006). Hexokinase (HXK) is an evolutionarily conserved Glc sensor in many organisms. In plants, it has dual functions in Glc metabolism as well as Glc sensing and signaling that modulate many physiological processes by integrating nutrient, light, and hormone signals (Moore et al., 2003; Rolland et al., 2006). The HXK1 loss-of-function glucose insensitive2-1 (gin2-1) and gin2-2 have been isolated through a mutant screen based on a high Glc (6%) repression assay, displaying inhibition of cotyledon expansion, chlorophyll accumulation, and shoot growth at the early stage of seedling development (Moore et al., 2003). Biochemical and physiological characterization of the mutants revealed that HXK1 can modulate both growth-promoting and growth-inhibiting responses depending on the growth