Glycemic index, glycemic load and cancer risk
Glycemic index, glycemic load and cancer risk
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DOI：
10.1093/annonc/mds235
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发表时间：
2013-01-01
影响因子：
50.5
通讯作者：
Mery, L.
中科院分区：
文献类型：
--
作者：
Hu, J.;La Vecchia, C.;Mery, L.
膳食血糖指数（GI）和血糖负荷（GL）与某些癌症的风险有关，但问题仍然悬而未决。1994年至1997年间，在加拿大八个省完成了邮寄调查问卷，调查了胃（n = 1182）、结肠（n = 1727）、直肠（n = 1447）、肝脏（n = 309）、胰腺（n = 628）、肺（n = 3341）、乳房（n = 2362）、卵巢（n = 442）、前列腺（n = 1799）、睾丸（n = 686）、肾（n = 1345）、膀胱（n = 1029）、脑（n = 1009）、非霍奇金淋巴瘤（NHL，n = 1666）、白血病（n = 1069）、多发性骨髓瘤（n = 343）和 5039 人群对照。使用经过验证的食物频率问卷 (FFQ) 获得参与者参加研究前 2 年的饮食习惯的饮食信息。比值比 (OR) 和 95% 置信区间 (CI) 通过无条件逻辑回归得出，包括公认的混杂因素。膳食 GI 与前列腺癌风险呈正相关（最高四分位数与最低四分位数的 OR 为 1.26）。较高的膳食GL会显着增加结直肠癌（OR，1.28）、直肠癌（OR，1.44）和胰腺癌（OR，1.41）的风险。没有发现其他显着关联。我们的研究结果表明，高 GI 和 GL 饮食与某些癌症的风险增加相关。
Dietary glycemic index (GI) and glycemic load (GL) have been related to the risk of selected cancers, but the issue remains open.Mailed questionnaires were completed between 1994 and 1997 in eight Canadian provinces for incident, histologically confirmed cases of the stomach (n = 1182), colon (n = 1727), rectum (n = 1447), liver (n = 309), pancreas (n = 628), lung (n = 3341), breast (n = 2362), ovary (n = 442), prostate (n = 1799), testis (n = 686), kidney (n = 1345), bladder (n = 1029), brain (n = 1009), non-Hodgkin's lymphomas (NHL, n = 1666), leukemias (n = 1069), multiple myelomas (n = 343), and 5039 population controls. Dietary information on eating habits 2 years before participants' enrollment in the study was obtained using a validated food frequency questionnaire (FFQ). Odds ratios (ORs) and 95% confidence intervals (CI) were derived by unconditional logistic regression including recognized confounding factors.Dietary GI was positively associated with the risk of prostate cancer (OR, 1.26 for the highest versus the lowest quartile). A higher dietary GL significantly increased the risk of colorectal (OR, 1.28), rectal (OR, 1.44) and pancreatic (OR, 1.41) cancers. No other significant associations were found.Our findings suggest that a diet high in GI and GL is associated with increased risk of selected cancers.