Neuropsychological impairments in neuroleptic-responder vs. -nonresponder schizophrenic patients and healthy volunteers
Neuropsychological impairments in neuroleptic-responder vs. -nonresponder schizophrenic patients and healthy volunteers
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DOI：
10.1016/s0920-9964(01)00279-1
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发表时间：
2002-01-15
影响因子：
4.5
通讯作者：
Benkelfat, C
中科院分区：
文献类型：
--
作者：
Joober, R;Rouleau, GA;Benkelfat, C
确定代表精神安定药反应谱两个极端的两组精神分裂症患者（一致反应者与一致无反应者）在神经心理学特征方面是否存在差异。根据先验定义的对典型精神安定药的反应标准，招募精神安定药有反应者（R；n = 36）和无反应者（NR；n = 39）精神分裂症患者。评估并比较了各组之间的七个神经心理学领域：注意力-警惕性、抽象-灵活性、空间组织、视觉-运动处理、视觉记忆、言语能力以及言语记忆和学习。所有测量均使用 36 名健康志愿者的分数进行标准化。与正常对照和 R 型精神分裂症患者相比，NR 型精神分裂症患者在所有神经心理学领域的表现均较差。然而，与 R 患者相比，NR 患者仅在视觉记忆、言语能力以及言语记忆和学习方面的表现明显较差。只有后一个域将 NR 患者与其他两组显着区分开来。 R 患者在所有领域的表现都处于中等水平。这份关于抗精神病药有反应和无反应的精神分裂症患者之间神经心理学特征差异的报告，增加了越来越多的证据，支持根据精神安定药的治疗反应来区分精神分裂症患者的价值。 (C) 2002 Elsevier Science B.V. 保留所有权利。
To determine whether two groups of schizophrenic patients representing the two extremes of the neuroleptic response-spectrum (consistent responders vs. consistent nonresponders) differ with respect to their neuropsychological profile. Neuroleptic-responder (R; n = 36) and -nonresponder (NR; n = 39) schizophrenic patients were recruited according to a priori defined criteria of responsiveness to typical neuroleptics. Seven neuropsychological domains were assessed and compared between groups: attention-vigilance, abstraction-flexibility, spatial organization, visual-motor processing, visual memory, verbal abilities, and verbal memory and learning. All measures were standardized using the scores of 36 healthy volunteers. NR schizophrenic patients performed worse in all neuropsychological domains compared to normal controls and R schizophrenic patients. However, only performances on visual memory, verbal abilities, and verbal memory and learning were significantly poorer in NR compared to R patients. Only the latter domain significantly differentiated NR patients from the other two groups. R patients performed at an intermediate level in all domains. This report of differences in neuropsychological profile between neuroleptic-responder and -nonresponder schizophrenic patients adds to the growing evidence supporting the value of distinguishing schizophrenic patients on the basis of their therapeutic response to neuroleptics. (C) 2002 Elsevier Science B.V. All rights reserved.