Decline in Adult Neurogenesis During Aging Follows a Topographic Pattern in the Mouse Hippocampus
Decline in Adult Neurogenesis During Aging Follows a Topographic Pattern in the Mouse Hippocampus
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DOI：
10.1002/cne.22527
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发表时间：
2011-02-15
影响因子：
2.5
通讯作者：
Jinno, Shozo
中科院分区：
文献类型：
--
作者：
Jinno, Shozo
在啮齿类动物的大脑中，不同的功能是地形分布在海马。例如，背侧海马体（隔）与空间记忆有关，而腹侧海马体（颞）与情绪和焦虑有关。越来越多的证据表明，海马神经发生的年龄依赖性下降与这些功能的损伤有关。然而，很少有人知道是否在衰老过程中的齿状颗粒细胞生产的下降遵循地形模式。在这里，我们定量估计特定群体的成年出生的细胞在年轻的成年和中年小鼠通过使用内源性标记，并确定是否年龄依赖性减少成年神经发生表现出地形差异。青年和中年小鼠背侧齿状回（DG）中初级祖细胞、中间神经元祖细胞和神经元谱系的数密度（ND）均高于腹侧DG，但背侧DG中ND与腹侧DG中ND的比值随年龄的增长而显著增加。这些人群的数量与年龄相关的减少是在腹侧DG比背侧DG。相反，在生活中，胶质细胞谱系的ND在腹侧DG中高于背侧DG，并且胶质细胞谱系的数量没有表现出明显的年龄相关性变化。我们的研究结果表明，在老化过程中，腹侧海马的神经发生，而不是胶质细胞的发生，衰减速度比背侧海马快。海马神经发生的这种与年龄相关的地形变化可能与老年人的记忆和情感障碍有关。神经学比较杂志519：451-466，2011. (C)2010 Wiley-Liss，Inc.
In the rodent brain, diverse functions are topographically distributed within the hippocampus. For instance, the dorsal (septal) hippocampus is involved in spatial memory, whereas the ventral (temporal) hippocampus is related to emotion and anxiety. Accumulating evidence shows that age-dependent decline in hippocampal neurogenesis is associated with impairments of these functions. However, little is known about whether the decline in dentate granule cell production during aging follows a topographic pattern. Here we quantitatively estimated specific populations of adult-born cells in young adult and middle-aged mice by using endogenous markers and determined whether age-dependent reductions in adult neurogenesis exhibited topographic differences. The numerical densities (NDs) of putative primary progenitors, intermediate neuronal progenitors, and neuronal lineages were higher in the dorsal dentate gyrus (DG) than in the ventral DG both in young adult and in middle-aged mice, but the ratios of the NDs in the dorsal DG to the NDs in the ventral DG noticeably increased with age. The age-related reductions in the numbers of these populations were larger in the ventral DG than in the dorsal DG. By contrast, the NDs of glial lineages were higher in the ventral DG than in the dorsal DG during life,, and the numbers of glial lineages showed no significant age-related changes. Our findings suggest that neurogenesis, but not gliogenesis, wanes faster in the ventral hippocampus than in the dorsal hippocampus during aging. Such age-related topographic changes in hippocampal neurogenesis might be implicated in memory and affective impairments in older people. J. Comp. Neurol. 519:451-466, 2011. (C) 2010 Wiley-Liss, Inc.