Are gender differences in schizophrenia reflected in brain event-related potentials?
Are gender differences in schizophrenia reflected in brain event-related potentials?
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精神分裂症的性别差异是否反映在大脑事件相关电位上？
DOI：
10.1093/schbul/16.2.229
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发表时间：
1990
影响因子：
6.6
通讯作者：
Shagass,C
中科院分区：
文献类型：
--
作者：
Josiassen,RC;Roemer,RA;Johnson,MM;Shagass,C
许多研究报道了性别与从人类头皮记录的脑事件相关电位（ERP）之间的关系。最近的研究表明，与健康对照组相比，精神分裂症患者的性别对ERP的影响可能有所不同。在进一步评估的影响，这一关键的主题变量对ERP特征的精神分裂症，ERP的年龄和性别匹配组（n=72）的未服药的精神分裂症患者和健康对照组进行了比较。从15个头皮导联记录了左、右正中神经刺激、棋盘格图形视觉闪光和听觉咔哒声诱发的ERPs。结果证实了以前的研究结果，即：（1）在这两个大的研究组的ERP记录中存在的可比较的性别效应的数量和（2）特定的诊断×性别的相互作用表明，精神分裂症疾病可能会改变ERP特征的正常性别影响。这些数据说明了一点，匹配精神分裂症患者和健康对照人群的性别是必要的，但还不够。即使在仔细匹配的组中，性别混杂也可能作为误差方差的来源而持续存在，因为不同诊断组的影响可能不同。
Numerous studies have reported relationships between gender and cerebral event-related potentials (ERPs) recorded from the human scalp. Recent studies have suggested that the influences of gender on ERPs may differ in persons with schizophrenia compared to healthy controls. In a further evaluation of the influences of this critical subject variable on ERP characteristics in schizophrenia, ERPs of age- and gender-matched groups (n=72 each) of unmedicated schizophrenic patients and healthy controls were compared. ERPs elicited by left and right median nerve stimulation, checkerboard pattern visual flash, and auditory clicks were recorded from 15 scalp leads. The results confirm previous findings showing that: (1) number of comparable gender effects present in the ERP records of these two large study groups and (2) specific Diagnosis × Gender interactions suggesting that schizophrenic illness may modify normal gender influences on ERP characteristics. These data illustrate the point that matching schizophrenic patients and healthy control populations for gender is essential but not sufficient. Even in carefully matched groups, gender confounding can persist as a source of error variance because the influence can vary for different diagnostic groups.