EFFECT OF AGE, PARITY, AND SMOKING ON PREGNANCY OUTCOME - A POPULATION-BASED STUDY
EFFECT OF AGE, PARITY, AND SMOKING ON PREGNANCY OUTCOME - A POPULATION-BASED STUDY
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DOI：
10.1016/s0002-9378(12)90878-9
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发表时间：
1993-01-01
影响因子：
9.8
通讯作者：
ISOTALO, L
中科院分区：
文献类型：
--
作者：
CNATTINGIUS, S;FORMAN, MR;ISOTALO, L
目的：本研究的目的是调查孕妇年龄、产次和吸烟对妊娠结局的综合交互作用。研究设计：这是一项以人群为基础的瑞典研究（n = 538，829）。多因素Logistic回归分析显示，吸烟-在经产患者中，低出生体重和早产的比值比相对增加的相关影响显著大于未经产的;在多次生育者中，吸烟使低出生体重和早产的比值比分别增加了2.4和1.6;在未生育者中，相应的比值比分别增加了1.7和1.1。随着母亲年龄的增长，吸烟相关的小于胎龄儿出生的优势比相对增加。此外，年龄对低出生体重，早产，和小的胎龄出生的相对增加的影响是更大的nulliferarians比multiferaries.CONCLUSIONS：老年吸烟者是在一个特别高的风险小的胎龄出生，和经产吸烟者是在一个特别高的风险低出生体重和早产。
OBJECTIVES: The purpose of our study was to investigate the combined interactive effects of maternal age, parity, and smoking on pregnancy outcome.STUDY DESIGN: This was a population-based Swedish study (n = 538,829).RESULTS: Multiple logistic regression analysis showed that the smoking-related effect on the relative increase in the odds ratio of low birth weight and preterm delivery was significantly greater among multiparous patients than nulliparous; among multiparas, smoking increased the odds ratios for low birth weight and preterm delivery by 2.4 and 1.6; the corresponding relative increases in the odds ratios among nulliparas were 1.7 and 1.1, respectively. With advancing maternal age there was a smoking-related relative increase in the odds ratios for small-for-gestational-age births. Moreover, the age effect on the relative increase of low birth weight, preterm delivery, and small-for-gestational-age births was greater among nulliparas than multiparas.CONCLUSIONS: Older smokers are at an especially high risk for small-for-gestational-age births, and parous smokers are at an especially high risk for low birth weight and preterm delivery.