Interaction of rice dwarf virus outer capsid P8 protein with rice glycolate oxidase mediates relocalization of P8
Interaction of rice dwarf virus outer capsid P8 protein with rice glycolate oxidase mediates relocalization of P8
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水稻矮缩病毒外衣壳P8蛋白与水稻乙醇酸氧化酶的相互作用介导P8的重新定位
DOI：
10.1016/j.febslet.2006.11.073
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发表时间：
2007-01
期刊：
影响因子：
3.5
通讯作者：
Li, Yi
中科院分区：
文献类型：
--
作者：
Zhou, Feng;Pu, Yingying;Deng, Wulan;Wu, Gang;Wei, Chunhong;Li, Yi
Yeast two-hybrid and coimmunoprecipitation assays indicated that P8, an outer capsid protein of Rice dwarf phytoreovirus (RDV), interacts with rice glycolate oxidase (GOX), a typical enzyme of peroxisomes. Confocal immunofluorescence microscopy revealed that P8 was colocalized with GOX in peroxisomes. Time course analysis demonstrated that the localization of P8 in Spodoptera frugiperda cells changed from diffuse to discrete, punctuate inclusions during expression from 24 to 48h post inoculation. Coexpression of GOX with P8 may target P8 into peroxisomes, which serve as replication sites for a number of viruses. Therefore, we conclude that the interaction of P8 with the GOX of host cells leads to translocation of P8 into peroxisomes and we further propose that the interaction between P8 and GOX may play important roles in RDV targeting into the replication site of host cells. Our findings have broad significance in studying the mechanisms whereby viruses target appropriate replication sites and begin their replication.
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影响因子：
3.7
作者：
L. Rubino;M. Russo
通讯作者：
L. Rubino;M. Russo
影响因子：
16.6
作者：
H. Van den bosch;R. Schutgens;R. Wanders;J. Tager
通讯作者：
H. Van den bosch;R. Schutgens;R. Wanders;J. Tager
影响因子：
5.4
作者：
Li, Y;Bao, YM;Nelson, RS
通讯作者：
Nelson, RS
DOI：
10.1002/j.1460-2075.1991.tb04889.x
发表时间：
1991-11
期刊：
The EMBO Journal
影响因子：
--
作者：
B. Swinkels;Stephen J. Gouldl;A. Bodnar;R. A. Rachubinski;Suresh Subramanil
通讯作者：
B. Swinkels;Stephen J. Gouldl;A. Bodnar;R. A. Rachubinski;Suresh Subramanil
DOI：
10.1016/s0021-9258(19)49726-3
发表时间：
1992-07
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Satoshi Miura;Izumi Kasuya-Arai;Hitoshi Mor;Shoko Miyazawag;Takashi OsumiOT;Takashi HashimotoO;Yukio Fujikill
通讯作者：
Satoshi Miura;Izumi Kasuya-Arai;Hitoshi Mor;Shoko Miyazawag;Takashi OsumiOT;Takashi HashimotoO;Yukio Fujikill