Cytotoxic cell vacuolating activity from Vibrio cholerae hemolysin
Cytotoxic cell vacuolating activity from Vibrio cholerae hemolysin
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DOI：
10.1128/iai.68.3.1700-1705.2000
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发表时间：
2000-03-01
影响因子：
3.1
通讯作者：
DiRita, VJ
中科院分区：
文献类型：
--
作者：
Coelho, A;Andrade, JRC;DiRita, VJ
一种霍乱弧菌细胞毒素，命名为VcVac，被发现在Vero细胞中引起空泡化。它最初在霍乱弧菌的致病性O1亚马逊变异株中检测到，后来证明在环境菌株和一些El - Tor菌株中产生。不同菌株的VcVac产量比较表明，溶血素是液泡表型的主要原因。基因实验证实了空泡形成和溶血素产生之间的紧密联系。霍乱弧菌溶血素的哺乳动物细胞空泡活性是该蛋白的新特性，并指出霍乱弧菌与其宿主之间以前未知的相互作用类型。
A Vibro cholerae cytotoxin, designated VcVac, was found to cause vacuolation in Vero cells. It was originally detected in the pathogenic O1 Amazonia variant of V cholerae and later shown to be produced in environmental strains and some El Tor strains. Comparison of VcVac production in various strains suggested that hemolysin was responsible for the vacuolating phenotype. Genetic experiments established a firm correlation between vacuolation and hemolysin production. The mammalian cell vacuolating activity of the V. cholerae hemolysin is a new property of this protein and points to a previously unknown type of interaction between V. cholerae and its host.