Emerging role of exosome-mediated intercellular communication in vascular remodeling.
Emerging role of exosome-mediated intercellular communication in vascular remodeling.
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外泌体介导的细胞间通讯在血管重塑中的新作用
DOI：
10.18632/oncotarget.14878
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发表时间：
2017-04-11
期刊：
影响因子：
--
通讯作者：
Xiang M
中科院分区：
文献类型：
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作者：
Su SA;Xie Y;Fu Z;Wang Y;Wang JA;Xiang M
血管重构是指血管系统功能和结构的改变。血管重塑涉及一组复杂的自分泌/旁分泌细胞相互作用。Exosome是一种新发现的天然纳米载体和细胞间信使，在调节细胞间通讯中起着关键作用。外泌体是血管重塑过程中的重要介质，在血管疾病的预后和治疗中显示出最大的潜力。由于外泌体的运输，血管系统既能维持生理状态下的功能和结构，又能适应病理状态。本文就外泌体在血管生成、内皮功能和心脏再生中的作用作一综述。此外，外泌体的含量在很大程度上取决于供体细胞的病理生理状态和外周微环境，这使得外泌体在血管疾病中表现出多效性。因此，外泌体在血管疾病，包括动脉粥样硬化，新生内膜形成和血管修复，原发性高血压，肺动脉高压，和主动脉瘤的不同影响将被讨论。最后，通过介绍工程化exosomes在临床上的最新应用，总结了exosomes的翻译应用。
Vascular remodeling refers to the alternations of function and structure in vasculature. A complex autocrine/paracrine set of cellular interaction is involved in vascular remodeling. Exosome, a newly identified natural nanocarrier and intercellular messenger, plays a pivotal role in regulating cell-to-cell communication. Exosome emerges as an important mediator in the process of vascular remodeling, showing the most prognostic and therapeutic potent in vascular diseases. Benefiting from exosomal trafficking, the vasculature can not only maintain its function and structure in physiological condition, but also adapt itself in pathological status. In this review, we will represent the roles of exosomes in angiogenesis, endothelial function and cardiac regeneration. In addition, greatly depending on the pathophysiological status of donor cells and peripheral micro-circumstance, the exosomal content could alter, which makes exosomes exhibit pleiotropic effects in vascular diseases. Hence, the diverse effects of exosomes in vascular diseases including atherosclerosis, neointima formation and vascular repair, primary hypertension, pulmonary artery hypertension, and aortic aneurysm will be discussed. Finally, the translational appliances targeting exosomes will be concluded by providing updated applications of engineered exosomes in clinic.