Plasma level of diethylcarbamazine in jirds and hamsters.
Plasma level of diethylcarbamazine in jirds and hamsters.
复制标题
沙鼠和仓鼠中二乙基卡马嗪的血浆水平。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
M. Niwa
中科院分区：
文献类型：
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作者：
E. Kimura;Y. Aoki;Y. Nakajima;M. Niwa
用气-液色谱方法研究了沙鼠和金黄地鼠二乙基氨马津(DEC)剂量与血药浓度的关系。沙鼠以100 mg/kg体重给药后，血药浓度迅速升高，10分钟达最大值(20-25微克/毫升)，4小时后迅速降至检测不到的水平。即使大剂量给药(300 mg/kg)，DEC在8小时内也能从血液循环中完全消除。当给予相同剂量的DEC时，仓鼠血液中的DEC水平比沙鼠血液中的DEC水平长2-4小时。以100 mg/kg胃管给药，在仓鼠体内的检测时间(8小时)比在沙鼠体内(2小时)长得多。重复给药时间表没有显示出药物累积的趋势。DEC在尿液和粪便中排泄，但药物排泄总量仅为给药量的8%左右。未代谢的DEC大部分在0~12小时内随尿排出。
The relation between the dosage and plasma level of diethylcarbamazine (DEC) in jirds and hamsters was examined by gas-liquid chromatography. When the drug was given intraperitoneally to jirds at 100 mg/kg body weight, the plasma level rose rapidly and reached the maximum level (20-25 micrograms/ml) at 10 minutes and afterwards fell quickly to undetectable level at 4 hours. Even if larger dosage (300 mg/kg) was given, DEC was eliminated completely from the blood circulation within 8 hours. When the same dosages of DEC were given intraperitoneally, the DEC levels remained 2-4 hours longer in the blood of hamsters than in the blood of jirds. DEC given by stomach intubation at 100 mg/kg remained detectable much longer in hamsters (8 hrs) than in jirds (2 hrs). A repeated doses schedule did not show a tendency for the drug to accumulate. DEC was excreted in the urine and feces, but the total amount of drug excreted without metabolic changes was only about 8% of the given dosage. The majority of unmetabolized DEC was excreted in the urine within 0-12 hours.