Impact of n-3 fatty acids on endothelial function: results from human interventions studies
Impact of n-3 fatty acids on endothelial function: results from human interventions studies
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DOI：
10.1097/mco.0b013e3283439622
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发表时间：
2011-03-01
影响因子：
3.1
通讯作者：
Stehle, Peter
中科院分区：
文献类型：
--
作者：
Egert, Sarah;Stehle, Peter
综述目的内皮功能障碍在动脉粥样硬化形成中起着不可或缺的作用。本文综述了海洋[二十碳五烯酸（EPA），二十二碳六烯酸（DHA）]和植物[α-亚麻酸（ALA）] n - 3多不饱和脂肪酸（PUFAs）对健康个体和具有心血管疾病（CVD）危险因素或明显CVD的患者的内皮功能的影响。3 PUFA对空腹和/或餐后内皮功能的影响。在健康个体中，定期补充EPA/DHA或ALA对内皮功能的结果不一致，而在超重血脂异常患者和2型糖尿病患者中，内皮功能标志物似乎得到改善。在CVD患者中观察到了缓解结果。研究结果之间的差异的原因包括健康状况和参与者的年龄，补充的持续时间，剂量和脂肪酸组成的管理n - 3 PUFAs以及用于评估内皮function.SummaryIn个人与CVD危险因素，包括超重，血脂异常和2型糖尿病n - 3 PUFAs可能会改善内皮功能。然而，临床疗效的证据还不足以就具体剂量和补充持续时间提出最终建议。
Purpose of reviewDysfunction of the endothelium plays an integral role in atherogenesis. This review summarizes recent findings on the effects of marine [eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)] and plant [alpha-linolenic acids (ALA)] n - 3 polyunsaturated fatty acids (PUFAs) on endothelial function in healthy individuals and in patients with cardiovascular disease (CVD) risk factors or manifest CVD.Recent findingsWe identified 33 intervention trials investigating the effects of n - 3 PUFA on fasting and/or postprandial endothelial function. In healthy individuals regular supplementation of EPA/DHA or ALA shows inconsistent results on endothelial function, whereas markers of endothelial function seem to be improved in overweight dyslipidaemic patients and type 2 diabetics. Conflicting results are observed in CVD patients. Reasons for discrepancies between the study results include the health status and age of participants, duration of supplementation, dose and fatty acid composition of the administered n - 3 PUFAs as well as methods used to assess endothelial function.SummaryIn individuals with CVD risk factors including overweight, dyslipidemia and type 2 diabetes n - 3 PUFAs may improve endothelial function. However, the evidence for a clinical efficacy is not strong enough to make final recommendations with respect to a specific dose and the duration of supplementation.