Patterned Multiplex Pathogen DNA Detection by Au Particle-on-Wire SERS Sensor
Patterned Multiplex Pathogen DNA Detection by Au Particle-on-Wire SERS Sensor
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DOI：
10.1021/nl1000086
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发表时间：
2010-04-01
期刊：
影响因子：
10.8
通讯作者：
Kim, Bongsoo
中科院分区：
文献类型：
--
作者：
Kang, Taejoon;Yoo, Seung Min;Kim, Bongsoo
开发了一种可用作特异性、灵敏性和多重DNA传感器的Au粒子在线系统。由多个Au纳米线传感器形成的图案为每个传感器提供位置地址和标识。通过使用该系统，目标DNA的多重传感可以以定量方式进行，检测限为10 pM。该传感器系统成功识别了参考细菌和临床分离株的目标DNA，从而能够诊断传染病。
A Au particle-on-wire system that can be used as a specific, sensitive, and multiplex DNA sensor is developed. A pattern formed by multiple Au nanowire sensors provides positional address and identification for each sensor. By using this system, multiplex sensing of target DNAs was possible in a quantitative manner with a detection limit of 10 pM. Target DNAs from reference bacteria and clinical isolates were successfully identified by this sensor system, enabling diagnostics for infectious diseases.