A new method for computing the uniaxial modulus of articular cartilages using modified inhomogeneous triphasic model
A new method for computing the uniaxial modulus of articular cartilages using modified inhomogeneous triphasic model
复制标题
改进的非均匀三相模型计算关节软骨单轴模量的新方法
DOI：
10.1007/s10409-009-0287-x
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发表时间：
2010-03-01
影响因子：
3.5
通讯作者：
Fan, Yubo
中科院分区：
文献类型：
--
作者：
Niu, Haijun;Wang, Qing;Fan, Yubo
众所周知，关节软骨结构和组织成分的细微变化可导致其退变。本文在Narmoneva等人提出的非均相三相模型的基础上，提出了一种改进的四参数分层非均相三相模型。该模型采用分段拟合的优化准则，利用超声测量的软骨膨胀应变数据，得到了软骨的单轴模量Ha，并预测了软骨的膨胀模式。结果表明，新方法比三参数非均匀三相模型和均匀模型能更准确地估计单轴弹性模量，并能有效地预测高度非均匀分布的退变关节软骨的膨胀应变。本研究可为探讨软骨的力学和材料特性提供补充信息，从而有助于骨关节炎相关疾病的诊断。
It is well known that subtle changes in structure and tissue composition of articular cartilage can lead to its degeneration. The present paper puts forward a modified layered inhomogeneous triphasic model with four parameters based on the inhomogeneous triphasic model proposed by Narmoneva et al. Incorporating a piecewise fitting optimization criterion, the new model was used to obtain the uniaxial modulusHa, and predict swelling pattern for the articular cartilage based on ultrasound-measured swelling strain data. The results show that the new method can be used to provide more accurate estimation on the uniaxial modulus than the inhomogeneous triphasic model with three parameters and the homogeneous mode, and predict effectively the swelling strains of highly nonuniform distribution of degenerated articular cartilages. This study can provide supplementary information for exploring mechanical and material properties of the cartilage, and thus be helpful for the diagnosis of osteoarthritis-related diseases.