Exercise‐induced acute renal failure in a girl with renai hypouricemia
Exercise‐induced acute renal failure in a girl with renai hypouricemia
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肾性低尿酸血症女孩运动诱发急性肾功能衰竭
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
S. Miyazaki
中科院分区：
文献类型：
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作者：
Tadashi Sato;T. Kuno;K. Tashiro;I. Fujita;S. Miyazaki
一名10岁的日本女孩在学校体育训练期间进行100米短跑后发生急性肾衰竭。跑步后，患者腰部剧烈疼痛，恶心和呕吐持续超过12小时。第二天早上，她被发现有轻度蛋白尿和急性肾衰竭（ARF）。血清肌酐和血尿素氮升高，但血清尿酸水平正常（3.1 mg/dL）。随着肾功能在随后几天内恢复，患者出现明显的低尿酸血症（0.6 mg/dL）。尽管肾性低尿酸血症和ARF之间的病理生理学关联尚不清楚，但氧自由基与缺血再灌注ARF的发病机制有关。运动前后，患者中性粒细胞受N-甲酰甲硫氨酸-亮氨酰-苯丙氨酸刺激产生的超氧化物水平均正常。对患有临界性低尿酸血症的患者及其父母进行吡嗪酰胺和丙磺舒试验，以确定其肾小管对尿酸的处理。结果显示，病人和她的母亲有一个次全重吸收缺陷，而父亲有缺陷的分泌后尿酸重吸收。
A 10‐year‐old Japanese girl developed acute renal failure following a 100‐meter dash during physical training at school. After the run, she experienced intense pain in the loins with nausea and vomiting lasting more than 12 h. On the following morning, she was found to have mild proteinuria and acute renal failure (ARF). Serum creatinine and blood urea nitrogen were elevated, but the serum uric acid level was normal (3.1 mg/dL). With recovery of renal function over the ensuing days, hypouricemia (0.6 mg/dL) became evident in the patient. Although the pathophysiological association between renal hypouricemia and ARF is not known, oxygen free radicals have been implicated in the pathogenesis for ischemic‐reperfusion ARF. Superoxide production by neutrophils stimulated by N‐formyl methionine leucyl‐phenylalanine was normal in the patient both before and following exercise. Pyrazinamide and probenecid tests were undertaken on both the patient and her parents, who had borderline hypouricemia, to determine their renal tubular handling of uric acid. Results showed that the patient and her mother had a subtotal reabsorption defect, while the father had defective postsecretory uric acid reabsorption.
影响因子：
15.9
作者：
PALLER, MS;HOIDAL, JR;FERRIS, TF
通讯作者：
FERRIS, TF