Vitamin D3 and brain development
Vitamin D3 and brain development
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DOI：
10.1016/s0306-4522(03)00040-x
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发表时间：
2003-01-01
期刊：
影响因子：
3.3
通讯作者：
Feron, F
中科院分区：
文献类型：
--
作者：
Eyles, D;Brown, J;Feron, F
大脑中存在维生素D受体的证据表明，这种维生素可能在这个器官中起到了一些作用。这项研究调查了维生素D-3是否在大脑发育过程中起作用。我们证明，缺乏维生素D-3的母亲所生的大鼠在出生时大脑发生了深刻的变化。皮质更长，但不是更宽，侧脑室扩大，皮质按比例变薄，整个脑组织有更多的细胞增殖。脑内神经生长因子和胶质细胞源性神经营养因子的含量减少，低亲和力神经营养因子受体p75(NTR)的表达减少。我们的发现表明，母亲维生素D3水平低对大脑发育有重要影响。(C)2003年IBRO。爱思唯尔科学有限公司出版。版权所有。
Evidence for the presence of the vitamin D receptor in brain implies this vitamin may have some function in this organ. This study investigates whether vitamin D-3 acts during brain development. We demonstrate that rats born to vitamin D-3-deficient mothers had profound alterations in the brain at birth. The cortex was longer but not wider, the lateral ventricles were enlarged, the cortex was proportionally thinner and there was more cell proliferation throughout the brain. There were reductions in brain content of nerve growth factor and glial cell line-derived neurotrophic factor and reduced expression of p75(NTR), the low-affinity neurotrophin receptor. Our findings would suggest that low maternal vitamin D3 has important ramifications for the developing brain. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.