Effects of Olfactory Training in Patients with Olfactory Loss
Effects of Olfactory Training in Patients with Olfactory Loss
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DOI：
10.1002/lary.20101
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发表时间：
2009-03-01
期刊：
影响因子：
2.6
通讯作者：
Huettenbrink, Karl-Bernd
中科院分区：
文献类型：
--
作者：
Hummel, Thomas;Rissom, Karo;Huettenbrink, Karl-Bernd
目的：嗅觉功能是已知的调制反复暴露于气味。这项调查的目的是嗅觉丧失的患者是否会受益于“训练”的气味，改善他们的一般嗅觉功能。据推测，嗅觉训练应产生两个改进的灵敏度对使用的气味在培训过程中和整体增加的嗅觉functions.Study Design：前瞻性研究进行了患者嗅觉dysfunction.Methods：一组患者进行的培训（n = 40），而另一部分没有（n = 16）。患者的排除标准为鼻窦疾病。嗅觉训练进行了为期12周。患者每天两次暴露于四种强烈的气味（苯乙醇：玫瑰，桉树醇：桉树，香茅醛：柠檬，丁香酚：丁香）。嗅觉测试在训练之前和之后使用“嗅棒”进行。（苯乙醇的阈值、气味辨别和气味识别测试）以及培训过程中使用的气味阈值测试。结果：与基线相比，训练患者的嗅觉功能有所增加，这被观察用于嗅棒测试分数和用于训练过程中的气味的阈值。相反，嗅觉功能在没有进行嗅觉训练的患者中没有变化。目前的研究结果表明，结构化的，短期暴露于选定的气味可能会增加嗅觉灵敏度。
Objectives: Olfactory function is known to be modulated by repeated exposure to odors. The aim of this investigation was whether patients with olfactory loss would benefit from "Training" with odors in terms of an improvement of their general olfactory function. It was hypothesized that olfactory Training should produce both an improved sensitivity towards the odors used in the Training process and an overall increase of olfactory function.Study Design: The prospective study was performed in patients with olfactory dysfunction.Methods: One group of patients performed the Training (n = 40), whereas another part did not (n = 16). Exclusion criteria for patients were sinunasal disease. Olfactory training was performed over a period of 12 weeks. Patients exposed themselves twice daily to four intense odors (phenyl ethyl alcohol: rose, eucalyptol: eucalyptus, citronellal: lemon, and eugenol: cloves). Olfactory testing was performed before and after training using the "Sniffin' Sticks" (thresholds for phenyl ethyl alcohol, tests for odor discrimination and odor identification) in addition to threshold tests for the odors used in the training process.Results: Compared to baseline, training patients experienced an increase in their olfactory function, which was observed for the Sniffin' Sticks test score and for thresholds for the odors used in the training process. In contrast, olfactory function was unchanged in patients who did not perform olfactory training. The present results indicate that the structured, short-term exposure to selected odors may increase olfactory sensitivity.