Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema.
Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema.
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DOI：
10.1186/1465-9921-7-53
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发表时间：
2006-03-30
影响因子：
5.8
通讯作者：
Brusselle, Guy G.
中科院分区：
文献类型：
--
作者：
Demedts, Ingel K.;Demoor, Tine;Bracke, Ken R.;Joos, Guy F.;Brusselle, Guy G.
慢性阻塞性肺疾病（COPD）的特征在于气道的慢性炎症和肺实质的进行性破坏，这一过程在大多数情况下是由吸烟引发的。该疾病的发展涉及几种机制：炎性细胞流入肺部（导致气道慢性炎症），蛋白水解和抗蛋白水解活性之间的不平衡（导致健康肺组织的破坏）和氧化应激。近年来，越来越多的研究表明，肺组织结构细胞凋亡可能是COPD发病的重要上游事件，是COPD发病的第四个重要机制。COPD患者肺中凋亡的肺泡上皮细胞和内皮细胞增加。由于这不能通过这些结构细胞增殖的增加来抵消，最终结果是肺组织的破坏和肺气肿的发展。来自动物模型的数据表明血管内皮生长因子（VEGF）在肺中诱导结构细胞凋亡中的作用。其他凋亡介质，如caspase-3和神经酰胺，可能是有趣的目标，以防止细胞凋亡和肺气肿的发展。在这篇综述中，将讨论细胞凋亡在COPD动物模型和人类受试者研究中的作用。目的是对细胞凋亡在COPD和肺气肿中的作用提供最新的总结。
Chronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation of the airways and progressive destruction of lung parenchyma, a process that in most cases is initiated by cigarette smoking. Several mechanisms are involved in the development of the disease: influx of inflammatory cells into the lung (leading to chronic inflammation of the airways), imbalance between proteolytic and anti-proteolytic activity (resulting in the destruction of healthy lung tissue) and oxidative stress. Recently, an increasing number of data suggest a fourth important mechanism involved in the development of COPD: apoptosis of structural cells in the lung might possibly be an important upstream event in the pathogenesis of COPD. There is an increase in apoptotic alveolar epithelial and endothelial cells in the lungs of COPD patients. Since this is not counterbalanced by an increase in proliferation of these structural cells, the net result is destruction of lung tissue and the development of emphysema. Data from animal models suggest a role for Vascular Endothelial Growth Factor (VEGF) in the induction of apoptosis of structural cells in the lung. Other mediators of apoptosis, such as caspase-3 and ceramide, could be interesting targets to prevent apoptosis and the development of emphysema. In this review, recent data on the role of apoptosis in COPD from both animal models as well as from studies on human subjects will be discussed. The aim is to provide an up to date summary on the increasing knowledge on the role of apoptosis in COPD and pulmonary emphysema.
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影响因子：
4.4
作者：
Gueders, MM;Balbin, M;Cataldo, DD
通讯作者：
Cataldo, DD
DOI：
10.1164/ajrccm.160.supplement_1.4
发表时间：
1999-11-01
影响因子：
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作者：
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通讯作者：
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影响因子：
9.6
作者：
Kanazawa, H;Yoshikawa, J
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