Cardiovascular effects of acute oxygen administration in healthy adults
Cardiovascular effects of acute oxygen administration in healthy adults
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DOI：
10.1097/00005344-200308000-00014
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发表时间：
2003-08-01
影响因子：
3
通讯作者：
Maxwell, SRJ
中科院分区：
文献类型：
--
作者：
Waring, WS;Thomson, AJ;Maxwell, SRJ
在当前的医疗实践中，通常给予补充氧气。然而，最近注意到某些患者的潜在不利血流动力学后果。急性高氧引起心血管反应的可能机制尚不清楚。在一系列随机、安慰剂对照研究中，采用经验证的非侵入性技术，研究了急性给氧对心率、血压、心输出量、全身血管阻力和压力反射敏感性的影响。采用静脉闭塞体积描记法研究了局部给药乙酰胆碱（一种内皮依赖性血管扩张剂）、硝普钠（一种内皮非依赖性血管扩张剂）和L-N-G-单甲基精氨酸（一种一氧化氮合酶抑制剂）后，给氧对前臂血流反应的影响。给氧1h后，心率（P < 0.01）和心脏指数（P < 0.05）降低，平均动脉压（P < 0.01）、体循环阻力（P <0.05）、大动脉僵硬度（P < 0.05）和压力反射敏感性（P < 0.05）升高。对隔离前臂床的血管反应没有影响。这些研究结果表明，氧气管理导致心血管功能的急性影响，这可能是重要的急性疾病的背景下。
Supplementary oxygen is commonly administered in current medical practice. However, attention has recently been drawn to the potentially disadvantageous hemodynamic consequences in certain patients. Possible mechanisms underlying the cardiovascular responses to acute hyperoxia are unclear. The effects of acute oxygen administration on heart rate, blood pressure, cardiac output, systemic vascular resistance, and baroreflex sensitivity were studied in a series of randomised, placebo-controlled studies in healthy individuals, using validated, non-invasive techniques. The effects of oxygen administration on forearm blood flow responses to locally administered acetylcholine, an endothelium-dependent vasodilator, sodium nitroprusside, an endothelium-independent vasodilator, and L-N-G-monomethylarginine, a nitric oxide synthase inhibitor, were studied using venous occlusion plethysmography. Oxygen administration for 1 hour caused a reduction in heart rate (P < 0.01) and cardiac index (P < 0.05), and an increase in mean arterial pressure (P < 0.01), systemic vascular resistance (P < 0.05), large artery stiffness (P < 0.05), and baroreflex sensitivity (P < 0.05). There were no effects on vascular responses in the isolated forearm bed. These findings indicate that oxygen administration causes acute effects on cardiovascular function, which might be important in the context of acute illness.