Effect of chronic pentagastrin, cholecystokinin, and secretin on pancreas of rats.
Effect of chronic pentagastrin, cholecystokinin, and secretin on pancreas of rats.
复制标题
慢性五肽胃泌素、胆囊收缩素和促胰液素对大鼠胰腺的影响。
DOI：
--
复制
发表时间：
1978
影响因子：
--
通讯作者：
M. Grossman
中科院分区：
文献类型：
--
作者：
H. Petersen;T. Solomon;M. Grossman
大鼠每日皮下给药5次（1.5 mg/kg）、20%纯天然胆囊收缩素（CCK, 37.5 Ivy dog U/kg）或分泌素（25微克/kg），连续给药15 d。CCK和分泌素对胰腺分泌的作用是次极大的，而pentagastrin对胃酸分泌的作用是最大的。pentagastrin组胰腺湿重增加12% (P < 0.01)， CCK组增加57% (P < 0.001)，分泌素组增加9% （P < 0.01）。在cck处理的大鼠中，胆囊收缩素反应的最大蛋白质和碳酸氢盐输出量与胰腺重量的增加成比例增加，但分泌素反应的最大碳酸氢盐和蛋白质输出量没有改变。分泌素处理的大鼠显示碳酸氢盐的基础分泌降低，对分泌素刺激的敏感性降低，但对分泌素和CCK的最大碳酸氢盐和蛋白质输出不变。用pentagastrin治疗胰腺对分泌素或CCK的反应没有显著变化。我们得出结论：1)反复注射胆囊收缩素引起的胰腺重量增加伴随着功能容量的成比例增加，反映在最大碳酸氢盐和蛋白质输出增加中，以响应胆囊收缩素；2)反复注射分泌素降低了胰腺对分泌素的敏感性，但没有改变最大碳酸氢盐反应。
Pentagastrin (1.5 mg/kg), 20% pure natural cholecystokinin (CCK, 37.5 Ivy dog U/kg) or secretin (25 microgram/kg) was given in a depot carrier subcutaneously to rats 3 times daily for 15 days. The dose of CCK and secretin was submaximal for pancreatic secretion, whereas the dose of pentagastrin was supramaximal for gastric acid secretion. The pancreatic wet weight increased by 12% (P less than 0.01) in the rats treated with pentagastrin, 57% (P less than 0.001) in those treated with CCK, and 9% (P less than 0.01) in those treated with secretin. In CCK-treated rats, the maximal protein and bicarbonate outputs in response to cholecystokinin increased proportionately to the increase in pancreatic weight, but maximal bicarbonate and protein outputs in response to secretin were unaltered. The secretin-treated rats showed a lowered basal secretion of bicarbonate and a lowered sensitivity to secretin stimulation, but the maximal bicarbonate and protein outputs to secretin and CCK were unchanged. Treatment with pentagastrin produced no significant changes in pancreatic responses to secretin or CCK. We conclude that 1) the increase in pancreatic weight produced by repeated injections of cholecystokinin was accompanied by proportional increase in functional capacity as reflected by the increased maximal bicarbonate and protein outputs in response to cholecystokinin, and 2) repeated administration of secretin decreased the sensitivity of the pancreas to secretin without altering maximal bicarbonate response.